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Standardizing the haemoglobin glycation index

机译：标准化血红蛋白糖化指数

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Aims A high haemoglobin glycation index (HGI) is associated with greater risk for hypoglycaemia and chronic vascular disease. Standardizing how the HGI is calculated would normalize results between research studies and hospital laboratories and facilitate the clinical use of HGI for assessing risk. Methods The HGI is the difference between an observed HbA1c and a predicted HbA1c obtained by inserting fasting plasma glucose (FPG) into a regression equation describing the linear relationship between FPG and HbA1c in a reference population. We used data from the 2005–2016 U.S. National Health and Nutrition Examination Survey (NHANES) to identify a reference population of 18,675 diabetes treatment–na?ve adults without self-reported diabetes. The reference population regression equation (predicted HbA1c?=?0.024 FPG?+?3.1) was then used to calculate the HGI and divide participants into low ( Results As previously reported in multiple studies, a high HGI was associated with black race independent of diabetes status, and with older age, higher BMI and higher CRP in normal and prediabetic but not diabetic participants. The mean HGI was 0.6% higher in self-reported diabetic adults. The HGI was not associated with plasma insulin, HOMA-IR or 2?h OGTT in participants classified as normal, prediabetic or diabetic. Conclusions The regression equation derived from this demographically diverse diabetes treatment–na?ve adult NHANES reference population is suitable for standardizing how the HGI is calculated for both clinical use and in research to mechanistically explain population variation in the HGI and why a high HGI is associated with greater risk for chronic vascular disease.
机译：旨在高血红蛋白糖糖糖蛋白（HGI）与低血糖和慢性血管疾病的风险更大。标准化HGI的计算方式如何正常化研究研究和医院实验室之间的结果，并促进HGI临床使用进行评估风险。方法HGI是观察到的HBA1C和通过将空腹葡萄糖（FPG）插入参考群中的FPG和HBA1C之间的线性关系而获得的预测HBA1C和预测的HBA1C之间的差异。我们使用来自2005 - 2016美国国家健康和营养考试调查（NHANES）的数据，以确定18,675名糖尿病治疗的参考人群 - 没有自我报告的糖尿病。然后参考人口回归方程（预测的HBA1C？=Δ0.024fpg？3.1）计算HGI并将参与者分成低（结果，如先前在多项研究中报告的结果，高HGI与独立于糖尿病的黑色比赛相关联状态，较旧的年龄，BMI较高和较高的CRP在正常和预先糖尿病，而不是糖尿病参与者。自我报告的糖尿病成年人中的平均HGI高0.6％。HGI与血浆胰岛素，HOMA-IR或2无关。与参与者的H ogtt分类为正常，预先脂肪酸或糖尿病。结论来自这种人群多样化的糖尿病的回归方程 - Na've成年人Nhanes参考种群适用于标准化HGI如何为临床使用和研究中的如何进行机械化解释HGI的人口变异以及为什么高HGI与慢性血管疾病的风险更大。

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