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首页> 外文期刊>Endocrinology, Diabetes & Metabolism >Effect of hypoglycaemia on measures of myocardial blood flow and myocardial injury in adults with and without type 1 diabetes: A prospective, randomised, open-label, blinded endpoint, cross-over study
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Effect of hypoglycaemia on measures of myocardial blood flow and myocardial injury in adults with and without type 1 diabetes: A prospective, randomised, open-label, blinded endpoint, cross-over study

机译：低血糖对患有1型糖尿病的成人心肌血流和心肌损伤措施的影响：一种前瞻性，随机，开放标签，盲终点，交叉研究

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Aims This study examined the effect of experimentally-induced hypoglycaemia on measures of myocardial blood flow and myocardial injury in adults with, and without, type 1 diabetes. Methods In a prospective, randomised, open-label, blinded, endpoint cross-over study, 17 young adults with type 1 diabetes with no cardiovascular risk factors, and 10 healthy non-diabetic volunteers, underwent hyperinsulinaemic-euglycaemic (blood glucose 4.5–5.5?mmol/L) and hypoglycaemic (2.2–2.5?mmol/L) clamps. Myocardial blood flow was assessed using transthoracic echocardiography Doppler coronary flow reserve (CFR) and myocardial injury using plasma high-sensitivity cardiac troponin I (hs-cTnI) concentration. Results During hypoglycaemia, coronary flow reserve trended non-significantly lower in those with type 1 diabetes than in the non-diabetic participants (3.54?±?0.47 vs. 3.89?±?0.89). A generalised linear mixed-model analysis examined diabetes status and euglycaemia or hypoglycaemia as factors affecting CFR. No statistically significant difference in CFR was observed for diabetes status ( p =?.23) or between euglycaemia and hypoglycaemia ( p =?.31). No changes in hs-cTnI occurred during hypoglycaemia or in the recovery period ( p =?.86). Conclusions A small change in CFR was not statistically significant in this study, implying hypoglycaemia may require more than coronary vasomotor dysfunction to cause harm. Further larger studies are required to investigate this putative problem.
机译：目的本研究检测了实验诱导的低血糖对心肌血流和成人心肌损伤措施的影响，患有1型糖尿病。在预期，随机，开放标签，盲，终点交叉研究中，17名年轻成年人，1型糖尿病，没有心血管危险因素，10名健康的非糖尿病志愿者，接受过高胰岛素血症 - Euglycay（血糖4.5-5.5 ？mmol / l）和低血糖（2.2-2.5？mmol / l）夹具。使用血浆高敏感性心肌肌钙蛋白I（HS-CTNI）浓度来评估心肌血流量进行评估。结果在低血糖期间，冠状动脉流量储备在1型糖尿病中的趋势下显着降低，而不是在非糖尿病参与者中（3.54？±0.47 Vs.3.89？±0.89）。广义的线性混合模型分析检测了糖尿病状态和Euglycaemia或低血糖作为影响CFR的因素。对于糖尿病状态，观察到CFR的统计学意义（p = 33）或euglycaemia和低血糖（p = 31）。在低血糖期或恢复期间没有发生HS-CTNI的变化（p = 366）。结论本研究中CFR的小变化在统计学上没有统计学意义，暗示低血糖可能需要多于冠状动脉血管传递功能障碍造成伤害。需要进一步的更大的研究来调查这个推定的问题。

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