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Cardiovascular complications in COVID‐19 patients with or without diabetes mellitus

机译:Covid-19患者或没有糖尿病的患者心血管并发症

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Introduction Coronavirus disease 2019 (COVID‐19) has become a major global crisis. Preliminary reports have, in general, indicated worse outcomes in diabetes mellitus (DM) patients, but the magnitude of cardiovascular (CV) complications in this subgroup has not been elucidated. Methods We included 142 patients admitted with laboratory‐confirmed COVID‐19 from April 1st to May 30th 2020; 71 (50%) had DM. We compared baseline demographics and study outcomes between those with or without DM using descriptive statistics. Multivariate logistic regression was used to estimate the adjusted odds ratio for the study outcomes in DM patients, compared to those without DM, stratified by age, sex and glycaemic control. CV outcomes of interest include acute myocarditis, acute heart failure, acute myocardial infarction, new‐onset atrial fibrillation and composite cardiovascular end‐point consisting of all individual outcomes above. Result Mean age was 58?years. The unadjusted rates were higher in DM patients compared to non‐diabetics for the composite cardiovascular end‐point (73.2% vs. 40.6% p ?.0001), acute myocarditis (36.6% vs. 15.5% p =?.004), acute heart failure (25.3% vs. 5.6% p =?.001), acute myocardial infarction (9.9% vs. 1.4% p =?.03) and new‐onset atrial fibrillation (12.7% vs. 1.4% p =?.009). After controlling for relevant confounding variables, diabetic patients had higher odds of composite cardiovascular end‐point, acute heart failure and new‐onset atrial fibrillation.
机译:介绍冠状病毒疾病2019(Covid-19)已成为全球主要危机。一般而言,初步报告表明糖尿病(DM)患者的较差的结果,但该亚组中的心血管(CV)并发症的幅度尚未得到阐明。方法我们包括142名患者,从4月1日到2020年4月30日到2020年4月30日达到了实验室确认的Covid-19; 71(50%)有DM。我们将基线人口统计学和使用描述性统计数据与或没有DM之间的研究结果进行了比较。与没有DM的人相比,使用多变量逻辑回归来估计DM患者中研究结果的调整后的差距,而受年龄,性别和血糖控制的分层。 CV结果包括急性心肌炎,急性心力衰竭,急性心肌梗死,新出现的心房颤动和复合心血管终点,包括上述所有个体结果。结果平均年龄为58岁。与复合心血管终点的非糖尿病患者相比,DM患者的未调节率较高(73.2%与40.6%的P& 0001),急性心肌炎(36.6%与15.5%p =Δ.004) ,急性心力衰竭(25.3%vs.5.6%p =α.001),急性心肌梗死(9.9%vs.1.4%p = 03)和新出现的心房颤动(12.7%与1.4%p =? .009)。在控制相关混淆变量之后,糖尿病患者的复合心血管终点的几率较高,急性心力衰竭和新出现的心房颤动。

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