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首页> 外文期刊>Endocrinology, Diabetes & Metabolism >Risk factors for Graves' Orbitopathy in surgical patients—Results of a 10‐year retrospective study with review of the literature
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Risk factors for Graves' Orbitopathy in surgical patients—Results of a 10‐year retrospective study with review of the literature

机译：手术患者在手术患者中的危险因素 - 审查文献综述10年的回顾性研究

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Introduction We investigated known (eg age, smoking, thyrotropin receptor autoantibody (TRAb)) and new risk factors (eg thyroid peroxidase autoantibodies (TPO‐Ab), thyroid size, or BMI) for Graves' disease (GD) and Graves' orbitopathy (GO), especially in combination with each other, to determine which factors play the most important role in the development of GO. Methods From 2008 to 2018, n =?500 patients with GD were included in this retrospective single‐centre case‐control study. N =?231 (46%) had a GO and n =?269 (54%) showed no GO. Differences in risk factors were determined by Mann‐Whitney U and chi‐square test. Combined influences of factors were examined by multivariable logistic regression. Results Age at first diagnosis of GD (OR?=?1.043, p ?.006), smoking status (OR?=?2.64, p ?.026) and TRAb (OR?=?1.046, p ?.01) had a significant impact on GO. The factors gender, TPO‐Ab titre, BMI, TSH titre, T3 and T4 were not significant. Conclusion As it has been shown in univariate analyses, smoking, age and TRAb levels have a negative impact on the onset and course of GD and GO. Via multivariable regression, we could additionally show that smoking is the most important factor out of those analysed. TRAb might be a helpful surrogate parameter in the assessment of the progress of GO and therefore might be one factor in the decision‐making process for potential early operative surgery. With regard to the hitherto unclear role of BMI, thyroid size and TPO‐Ab in the course of GO, this study could not find any clinically relevant influence.
机译：介绍我们所研究的已知（例如年龄，吸烟，替代肾上腺素受体自身抗体（Trab））和新的风险因素（例如甲状腺过氧化物酶自身抗体（TPO-AB），甲状腺疾病（GD）和Graves'胰腺病（ GO），特别是彼此结合，确定哪些因素在去发展中发挥着最重要的作用。方法从2008到2018年，N =？500例GD患者包括在这个回顾性单中心病例对照研究中。 n =？231（46％）有一个Go，n =？269（54％）没有出现。风险因素的差异由Mann-Whitney U和Chi-Square测试确定。通过多变量的逻辑回归检查因素的综合影响。结果年龄在第一诊断Gd（或？=Δ1.043，p＆ 006），吸烟状态（或？=Δ2.64，p <。026）和trab（或？=？1.046，P＆ ？.01）对GO有重大影响。性别，TPO-AB滴度，BMI，TSH滴度，T3和T4不显着。结论由于单变量分析，吸烟，年龄和TRAB水平对GD的发病和过程产生负面影响。通过多变量的回归，我们还可以表明吸烟是分析的最重要因素。 TRAB可能是在评估进入的进展中有用的代理参数，因此可能是潜在的早期手术手术的决策过程中的一个因素。关于BMI，甲状腺大小和TPO-AB的迄今不明确的作用，本研究无法找到任何临床相关的影响。

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