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首页> 外文期刊>Endocrinology, Diabetes & Metabolism >Assessment of insulin resistance in patients with primary hyperparathyroidism before and after Parathyroidectomy
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Assessment of insulin resistance in patients with primary hyperparathyroidism before and after Parathyroidectomy

机译：在甲状旁腺切除术前后原发性甲状旁腺功能亢进症患者胰岛素抵抗的评估

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Background Primary hyperparathyroidism (PHPT) can lead to renal and skeletal disorders, as well as insulin resistance and impaired glucose metabolism. The current study aimed to assess the effects of parathyroidectomy on insulin resistance in patients with PHPT. Materials and Methods The present study was conducted on 65 patients with PHPT and indications for parathyroidectomy who were referred to the endocrinology clinics of Mashhad University of Medical Sciences. Thereafter, the demographic characteristics of the patients were recorded. Blood tests, including haemoglobin A1c (HbA1c), fasting blood glucose (FBG) and insulin levels, were assessed one week before and three months after the surgery. The insulin resistance score (HOMA-IR) was calculated and compared using the relevant formula. Results A total of 65 participants with a mean age of 45.44 ± 9.59?years were included in the current study. In one-month postoperative tests, mean scores of FBG ( p ?.05), insulin level ( p ?.05) and HbA1c ( p ?.05) were significantly reduced. Moreover, the HOMA-IR index decreased in 51 patients after the surgery. Conclusion According to our findings, parathyroidectomy can be effective in the reduction of insulin resistance and corresponding complications in patients with PHPT in the present short-term study. However, it has yet to be confirmed as a treatment method for insulin resistance in these patients. Future long-term studies are required to be done to investigate the effect of parathyroidectomy on insulin resistance.
机译：背景技术原发性甲状旁腺功能亢进（PHPT）可以导致肾病和骨骼疾病，以及胰岛素抵抗和葡萄糖代谢受损。目前的研究旨在评估甲状旁腺切除术对PHPT患者胰岛素抗性的影响。材料和方法本研究于65名患有65名患有甲羟吲哚菌切除术的患者的患者进行，甲露甲醛切除术称为MASHHAD医学院大学内分泌诊所。此后，记录患者的人口特征。在手术后三个月和三个月内评估血液试验，包括血红蛋白A1C（HBA1C），空腹血糖（FBG）和胰岛素水平。计算胰岛素抵抗评分（HOMA-IR）并使用相关公式进行比较。结果总共65名参与者，平均年龄为45.44±9.59岁？当前的研究中包含年龄。在一个月的术后试验中，平均FBG的分数（P＆ 05），胰岛素水平（p <。05）和Hba1c（p <。05）显着降低。此外，在手术后51名患者中，HOMA-IR指数降低。结论根据我们的研究结果，甲状旁腺切除术可以有效降低胰岛素抵抗和PHPT患者在本短期研究中的相应并发症。然而，尚未证实这些患者胰岛素抵抗的治疗方法。需要进行未来的长期研究以探讨甲状旁腺切除术对胰岛素抵抗的影响。

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