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首页> 外文期刊>Endocrinology, Diabetes & Metabolism >Early initiation of sodium‐glucose linked transporter inhibitors (SGLT‐2i) and associated metabolic and electrolyte outcomes in diabetic kidney transplant recipients
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Early initiation of sodium‐glucose linked transporter inhibitors (SGLT‐2i) and associated metabolic and electrolyte outcomes in diabetic kidney transplant recipients

机译：糖尿病肾移植受者的早期葡萄糖连接转运蛋白（SGLT-2I）和相关代谢和电解质结果的早期开始

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There is a paucity of data on the use of SGLT2 inhibitors on outcomes in kidney transplant recipients. There may be concern in initiating these agents, especially within thefirst year post-transplant when renal function is more labile and immunosuppressionmore intense, due to a presumed high risk of urinary infections and acute kidneyinjury. This is a retrospective study on 50 kidney transplant recipients, half of whomwere started on therapy within the first year of transplant. Over a follow-up periodof 6 months, overall patients had a statistically significant improvement in weight by?2.95 kg [SD 3.54, P = .0001 (CI: 3.53, 1.50)] as well as hypomagnesemia 0.13 [SD1.73, P = .0004 (CI: 0.06, 0.20)]. Overall insulin usage declined by ?3.7 units [SD 22.8,P = .17]. 14% of patients had at least one urinary tract infection although this rate isnot different (~20%) than that reported historically in this high-risk population.
机译：有没有关于在肾移植受者的结果上使用SGLT2抑制剂的数据。 当肾功能更加不稳定和免疫抑制更多的尿液感染和急性肾儿所时，可能有担心移植后的前进年内，特别是在移植后的前进症中。 这是对50例肾移植受者的回顾性研究，其中一半的人在移植的第一年开始治疗。 在6个月的后续期间，整体患者的重量均有统计学上显着的改善？2.95 kg [SD 3.54，P =＆ .0001（CI：3.53,1.50）]以及低钠血症0.13 [SD1.73， P = .0004（CI：0.06,0.20）]。 总体胰岛素使用情况下降？3.7单位[SD 22.8，P = .17]。 14％的患者患有至少一个尿路感染，尽管这种速率不同（〜20％）比历史上在这种高风险的人群中所报告。

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