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首页> 外文期刊>Mayo Clinic Proceedings: Innovations, Quality & Outcomes >Premature Myocardial Infarction: A Community Study
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Premature Myocardial Infarction: A Community Study

机译：早产心肌梗死：社区研究

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Objective To evaluate the trends in incident premature myocardial infarction (MI) and prevalence of cardiac risk factors in a population-based cohort. Methods We studied a population-based cohort of incident premature MIs among residents (MI in men aged 18-55 years and women aged 18-65 years) in Olmsted County, Minnesota, during a 26-year period from January 1, 1987 through December 31, 2012. Recurrent MI and death after incident premature MI were enumerated through September?30, 2018. Results Of 3276 MI cases, 850 were premature events (37.9% [322/850] women). Age-adjusted premature MI incidence rates (2012 vs 1987) declined by 39% in men (rate ratio, 0.61; 95% CI, 0.46 to 0.81]) and 61% in women (rate ratio, 0.39; 95% CI, 0.27 to 0.57). Among men with premature MI, the prevalence of hypertension, diabetes, and hyperlipidemia increased over time, whereas in women, only the prevalence of hyperlipidemia increased. During a mean follow-up of 13.3 years, there was no temporal decline in recurrent MI in men and women. Women showed 66% decreased risk for mortality (hazard ratio, 0.34; 95% CI, 0.17 to 0.68) over time, whereas men showed no change. Conclusion The incidence of premature MI declined over a 26-year period for both men and women. The risk factor profile of persons presenting with MI worsened over time, especially in men. Death following incident MI declined only in women. These results underscore the importance of primary prevention in young adults and of sex-specific approaches.
机译：目的评价事件过早心肌梗死（MI）的趋势及基于人群群体心脏风险因素的患病率。方法在明尼苏达州奥尔姆斯特郡（18-55岁），明尼苏达州，在1987年1月1日至12月，在明尼苏达州奥姆斯特德县（18-55岁及18-65岁）的居民（18-55岁及18至65岁的妇女的MI）中，研究了基于人口的事件过早MIS队。 2012年3月31日，事故过早MI的反复性MI和死亡被列举了9月30日？2018年30日。3276英里案件的结果为850例，为早产事件（37.9％[322/850]妇女）。年龄调整的早期MI发病率（2012年VS 1987）在男性中下降39％（率比，0.61; 95％CI，0.46至0.81]）和61％（率比率，0.39; 95％CI，0.27。 0.57）。在患有过早的MI的男性中，高血压，糖尿病和高脂血症的患病率随着时间的推移而增加，而在女性中，只有高脂血症的患病率增加。在13.3岁的平均随访期间，男女在经常性MI中没有时间下降。妇女表现出66％的死亡风险减少（危险比，0.34; 95％CI，0.17至0.68）随着时间的推移，而男性没有变化。结论男女过早MI的发病率下降了26年代男女。用mi呈现的人的风险因素概况随着时间的推移而恶化，特别是在男性身上。事件后的死亡仅在女性中拒绝。这些结果强调了青年成年人和性别特定方法中初步预防的重要性。

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