Role of the Cell Cycle in Collective Cell Dynamics

Jintao Li; Simon K. Schnyder; Matthew S. Turner; Ryoichi Yamamoto

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Role of the Cell Cycle in Collective Cell Dynamics

机译：细胞周期在集体细胞动态中的作用

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Cells coexist together in colonies or as tissues. Their behavior is controlled by an interplay between intercellular forces and biochemical regulation. We develop a simple model of the cell cycle, the fundamental regulatory network controlling growth and division, and couple this to the physical forces arising within the cell collective. We analyze this model using both particle-based computer simulations and a continuum theory. We focus on 2D colonies confined in a channel. These develop moving growth fronts of dividing cells with quiescent cells in the interior. The profile and speed of these fronts are nontrivially related to the substrate friction and the cell-cycle parameters, providing a possible approach to measure such parameters in experiments.

机译：细胞在菌落中共存在一起或作为组织。它们的行为是通过间细胞间力和生物化学调节之间的相互作用来控制的。我们开发了一个简单的细胞周期模型，基本的监管网络控制增长和分裂，并将其耦合到细胞集体内产生的物理力量。我们使用基于粒子的计算机模拟和连续文学理论来分析该模型。我们专注于在渠道中限制的2D殖民地。这些在内部的静态细胞中发育了分割细胞的移动生长前线。这些前沿的轮廓和速度与基板摩擦和细胞循环参数是非移动的，提供了测量实验中的这种参数的可能方法。

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《Physical Review X》 |2021年第3期|共17页
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Jintao Li; Simon K. Schnyder; Matthew S. Turner; Ryoichi Yamamoto;
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1. Yeast RAD2, a homolog of human XPG, plays a key role in the regulation of the cell cycle and actin dynamics Yeast RAD2, a homolog of human XPG, plays a key role in the regulation of the cell cycle and actin dynamics Yeast RAD2, a homolog of human XPG, plays a key role in the regulation of the cell cycle and actin dynamics [J] . Ho-Yeol Kim, Byung Hyune Choi, Mi-Sun Kang, Biology Open . 2014,第1期

机译：酵母RAD2，人类XPG的同源物，在细胞周期和肌动蛋白动力学的调节中起关键作用酵母RAD2，人类XPG的同源物，在细胞周期和肌动蛋白动力学的调节中起关键作用。 XPG的同系物，在调节细胞周期和肌动蛋白动力学中起关键作用
2. Gene expression waves - Cell cycle independent collective dynamics in cultured cells [J] . Tsuchyia M, Wong ST, Yeo ZX, The FEBS journal . 2007,第11期

机译：基因表达波-培养细胞中与细胞周期无关的集体动力学
3. Control of cell-cell forces and collective cell dynamics by the intercellular adhesome [J] . Bazellieres Elsa, Conte Vito, Elosegui-Artola Alberto, Nature cell biology . 2015,第4期

机译：细胞间胶体控制细胞力和集体细胞动力学
4. Analysis of cell cycle dynamics using probabilistic cell cycle models [C] . Gurkan-Cavusoglu Evren, Schupp Jane E., Kinsella Timothy J., 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2011

机译：使用概率细胞周期模型分析细胞周期动力学
5. Discerning the role of LMO4 as a global modulator of G2/M cell cycle progression and centrosome cycle in breast cancer cells. [D] . Montanez-Wiscovich, Marjorie E. 2010

机译：认识到LMO4作为乳腺癌细胞中G2 / M细胞周期进程和中心体周期的整体调节剂的作用。
6. Control of cell-cell forces and collective cell dynamics by the intercellular adhesome [O] . Elsa Bazellières, Vito Conte, Alberto Elosegui-Artola, -1

机译：细胞间胶体控制细胞力和集体细胞动力学
7. GENE EXPRESSION WAVES: CELL CYCLE INDEPENDENT COLLECTIVE DYNAMICS IN CULTURED CELLS [O] . TSUCHYIA M, WONG S.T, YEO Z.X, 2007

机译：基因表达波：培养细胞中细胞周期独立的集体动力学。

Role of the Cell Cycle in Collective Cell Dynamics

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