...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Physical Review X >Virus-Host Interactions Shape Viral Dispersal Giving Rise to Distinct Classes of Traveling Waves in Spatial Expansions
【24h】

Virus-Host Interactions Shape Viral Dispersal Giving Rise to Distinct Classes of Traveling Waves in Spatial Expansions

机译：病毒 - 宿主相互作用形状的病毒分散在空间扩展中产生不同的行进波浪

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Reaction-diffusion waves have long been used to describe the growth and spread of populations undergoing a spatial range expansion. Such waves are generally classed as either pulled, where the dynamics are driven by the very tip of the front and stochastic fluctuations are high, or pushed, where cooperation in growth or dispersal results in a bulk-driven wave in which fluctuations are suppressed. These concepts have been well studied experimentally in populations where the cooperation leads to a density-dependent growth rate. By contrast, relatively little is known about experimental populations that exhibit density-dependent dispersal. Using bacteriophage T7 as a test organism, we present novel experimental measurements that demonstrate that the diffusion of phage T7, in a lawn of host E. coli , is hindered by steric interactions with host bacteria cells. The coupling between host density, phage dispersal, and cell lysis caused by viral infection results in an effective density-dependent diffusion coefficient akin to cooperative behavior. Using a system of reaction-diffusion equations, we show that this effect can result in a transition from a pulled to pushed expansion. Moreover, we find that a second, independent density-dependent effect on phage dispersal spontaneously emerges as a result of the viral incubation period, during which, phage is trapped inside the host unable to disperse. Additional stochastic agent-based simulations reveal that lysis time dramatically affects the rate of diversity loss in viral expansions. Taken together, our results indicate both that bacteriophage can be used as a controllable laboratory population to investigate the impact of density-dependent dispersal on evolution, and that the genetic diversity and adaptability of expanding viral populations could be much greater than is currently assumed.
机译：反应扩散波长期以来用于描述经历空间范围扩张的人群的生长和传播。这种波通常被归类为拉动，其中动力学由前部的非常尖端和随机波动的尖端驱动，或者推动，其中生长或分散的协作导致抑制波动的体积驱动波。这些概念在实验上进行了很好地研究，合作导致密度依赖的增长率。相比之下，关于表现出密度依赖性分散的实验群体相对较少。使用噬菌体T7作为测试生物，我们提出了一种新的实验测量，证明噬菌体大肠杆菌草坪在宿主大肠杆草坪中的扩散被与宿主细胞细胞的空间相互作用受到阻碍。由病毒感染引起的宿主密度，噬菌体分散和细胞裂解之间的偶联导致类似于合作行为的有效密度依赖性扩散系数。使用反应扩散方程的系统，我们表明这种效果可能导致从拉动推动扩展的过渡。此外，我们发现，由于病毒潜伏期，在鼠中的噬菌体分散的噬菌体分散的依赖性效应是自发的，在此期间被捕获在宿主内部无法分散。额外的随机剂的模拟显示，裂解时间显着影响病毒扩展的分集损失率。我们的结果表明，噬菌体可以用作可控实验室人群，以研究密度依赖性分散对演化的影响，并且遗传多样性和扩大病毒群的适应性可能大得多比目前的假设要大得多。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号