...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Virulence. >Treading a HOSTile path: Mapping the dynamic landscape of host cell–rotavirus interactions to explore novel host-directed curative dimensions
【24h】

Treading a HOSTile path: Mapping the dynamic landscape of host cell–rotavirus interactions to explore novel host-directed curative dimensions

机译：踩一个敌对路径：映射宿主细胞rotavirus相互作用的动态景观，以探索新的宿主定向的治疗尺寸

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Viruses are intracellular pathogens and are dependent on host cellular resources to carry out their cycles of perpetuation. Obtaining an integrative view of host–virus interaction is of utmost importance to understand the complex and dynamic interplay between viral components and host machineries. Besides its obvious scholarly significance, a comprehensive host–virus interaction profile also provides a platform where from host determinants of pro-viral and antiviral importance can be identified and further be subjected to therapeutic intervention. Therefore, adjunct to conventional methods of prophylactic vaccination and virus-directed antivirals, this host-targeted antiviral approach holds promising therapeutic potential. In this review, we present a comprehensive landscape of host cellular reprogramming in response to infection with rotavirus (RV) which causes profuse watery diarrhea in neonates and infants. In addition, an emphasis is given on how host determinants are either usurped or subverted by RV in course of infection and how therapeutic manipulation of specific host factors can effectively modulate the RV life cycle.
机译：病毒是细胞内病原体，依赖于宿主细胞资源来进行它们的永久性循环。获取宿主互动的集成视图至关重要，以了解病毒组件和主机机械之间的复杂和动态相互作用。除了其明显的学术意义外，综合宿主病毒互动分布还提供了一种平台，其中来自宿主的宿主和抗病毒重要性，可以识别并进一步遭受治疗干预。因此，该宿主靶向抗病毒方法辅向预防性疫苗接种和病毒为导向的抗病毒方法，该宿主靶向抗病毒方法具有承担有前途的治疗潜力。在这篇综述中，我们呈现了宿主细胞重新编程的综合景观，以应对RotaVirus（RV）的感染，这导致新生儿和婴儿的丰富水腹泻。此外，在感染过程中，对宿主决定簇的篡改或颠覆宿主决定簇的重点以及特定宿主因子的治疗性如何有效地调节RV生命周期。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号