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Sensitive period for the plasticity of alpha activity in humans

机译：人类α活性的敏感期

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Visual experience is crucial for the development of neural processing. For example, alpha activity development is a vision-dependent mechanism. Indeed, studies report no alpha activity is present in blind adults. Nevertheless, studies have not investigated the developmental trajectory of this activity in infants and children with blindness. Here, we hypothesize that the difference in neural activity of blind compared to sighted subjects is: absent at birth, progressive with age, specifically occipital and linked to a gradual motor impairment. Therefore, we consider spectral power of resting-state EEG and its association with motor impairment indices, in blind subjects and in sighted controls between 0 and 11 years of age. Blind subjects show posterior alpha activity during the first three years of life, although weaker and slower maturing compared to sighted subjects. The first great differentiation between blind and sighted subjects occurs between 3 and 6 years of age. Starting in this period, reduced alpha activity increases the probability of motor impairment in blind subjects, likely because of impaired perception/interaction. These results show that visual experience mediates the neural mechanisms generating alpha oscillations during the first years of life, suggesting that it is a sensitive period for the plasticity of this process.
机译：视觉体验对于神经处理的发展至关重要。例如，alpha活动发展是一种视觉依赖机制。实际上，研究报告没有alpha活性存在于盲目的成年人中。尽管如此，研究没有调查婴儿和盲目儿童的这种活动的发育轨迹。在这里，我们假设与视力对象相比的盲目的神经活动差异是：在出生时缺席，随着年龄的增长，特别是痛苦和与逐渐的电机损伤相关。因此，我们考虑休息状态EEG的光谱力量及其与电机损伤指数，在盲目的主题中以及在0到11岁之间的视线控制中的频谱力量。盲目的受试者在生命的前三年中显示后α活动，尽管与视力的主题相比较弱和更慢。盲人和观察受试者之间的第一个巨大差异发生在3至6岁之间。从这个时期开始，减少的alpha活动增加了盲目主题的电机损伤的可能性，可能因为感知/互动受损。这些结果表明，视觉体验介导在生命的第一年内产生α振荡的神经机制，这表明它是该过程的可塑性的敏感时期。

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