Fractional Order Control of the Combined Anaesthesia-Hemodynamic System: a Preliminary Study

Erwin Hegedus; Isabela Birs; Cristina Muresan

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Fractional Order Control of the Combined Anaesthesia-Hemodynamic System: a Preliminary Study

机译：组合麻醉 - 血流动力学系统的分数控制：初步研究

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Most surgical interventions involve sedating the patient with a cocktail of substances having anesthetic effects. The procedure is usually performed by a medical doctor that continuously monitors and readjusts drug dosage with respect to the patient’s response. Current advances in automatic control and biomedical engineering offer the possibility to reassign the anesthetist’s task to real-time, highly-performant monitoring and control algorithms, with the purpose of providing a risk-free anesthetic experience. The present study combines the well-known benefits of fractional calculus in biomedical applications with the intricate tasks revolving around automatic anesthesia. The proposed fractional order control algorithms are developed based on an open-source patient simulator that combines hemodynamics and anesthesia in a single customizable framework. Testing and validation of the proposed strategy is successfully performed on a group of 24 different patients in the presence of surgical stimulus. The ultimate result is that the hemodynamic characteristics are kept within accepted ranges, while a certain level of anesthesia is achieved.

机译：大多数手术干预涉及用具有麻醉效应的鸡尾酒镇静患者。该过程通常由医生进行，该医生连续监测和重新调整药物剂量的药物剂量，患者的反应。目前在自动控制和生物医学工程方面的进步提供了将麻醉师任务重新分配到实时，高度性能的监测和控制算法的可能性，目的是提供无风险的麻醉体验。本研究将分数微积分在生物医学应用中的众所周知的益处与围绕自动麻醉的复杂任务相结合。所提出的分数顺序控制算法是基于开源患者模拟器开发的，该患者模拟器将血液动力学和麻醉中的单一可自定义框架组合。在外科刺激的存在下，成功地对拟议策略的测试和验证成功进行了一组24例不同患者。最终结果是血流动力学特性保持在接受的范围内，而达到一定程度的麻醉。

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《IFAC PapersOnLine》 |2021年第15期|共6页
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Erwin Hegedus; Isabela Birs; Cristina Muresan;
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fractional calculushemodynamics controlanesthesia controlsurgical stimulusautomatic control;

机译：分数计算血流动力学控制胰管控制刺激刺激;

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Fractional Order Control of the Combined Anaesthesia-Hemodynamic System: a Preliminary Study

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