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From batch to continuous tablet manufacturing: a control perspective

机译：从批量到连续片剂制造：控制透视

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摘要

Despite manufacturing innovations and the technologies on the rise, solid oral dosage in the pharmaceutical industry is still mass production. Although this is efficient and cost-effective, it is typically based on a ‘one-size-fits-all’ product concept and lacks the flexibility and agility required to fully meet the needs of the individual patient. Nowadays pharmaceutical industry is experiencing a paradigm shift from batch to continuous manufacturing. This will lead to increased flexibility to target diverse populations as well as more consistent product quality to ensure best efficacy. Continuous processing integrated with online/inline monitoring tools coupled with an efficient automatic feedback control system is highly desired by the pharmaceutical industry. To facilitate the transition from the batch wise production to continuous manufacturing in the pharma industry engineering tools are needed. Hence, the aim of this paper is to enhance the advantage of modeling and control techniques in the field of pharmaceutical applications.
机译：尽管制造创新和技术崛起，制药行业的固体口服剂量仍然批量生产。虽然这是高效且经济高效的，但它通常基于“单尺寸适合 - 所有”产品概念，并且缺乏完全满足各个患者需求所需的灵活性和敏捷性。如今制药行业正在经历从批量转移到连续制造的范式转变。这将导致针对靶向各种人口的灵活性以及更一致的产品质量，以确保最佳效力。制药行业非常需要与在线/内联监测工具集成的连续处理是高效的自动反馈控制系统。为了便于从批量明智的生产转变，以在制药工业工程工具中持续制造。因此，本文的目的是提高药物应用领域建模和控制技术的优势。

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