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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Clinico-epidemiological and Outcome of Scrub Typhus in Paediatric Patients: An Observational Study from Odisha, Indi
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Clinico-epidemiological and Outcome of Scrub Typhus in Paediatric Patients: An Observational Study from Odisha, Indi

机译：儿科患者培养毛刺的临床流行病学和结果：Odisa，Indi的观察研究

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Scrub typhus is re-emerging as a common prolonged febrile illness in children with serious complication involving major organ systems. It is easily treatable yet treatment is challenging with respect to early identification of predictors of serious disease that greatly affects the outcome in this vulnerable population.Aim: To study the clinical profile, analyse the complication and outcome of these patients.Materials and Methods: This was a hospital-based, prospective observational study. It was conducted in the Department of Paediatrics, SCB Medical College and Hospital, Cuttack from October 2017 to September 2019. All children with clinical features of scrub typhus were subjected to Immunoglobulin M (IgM) scrub typhus test. All observational data were analysed by IBM Statistical Package for the Social Science (SPSS) software, version 25.0 and Chi-square test was used with p<0.05 as statistically significant.Results: Out of total 196 subjects, majority 87 (44.4%) were found to be in the age group of 1-5 years of age and majority were males (55.1%). Fever was universally present (100%). Eschar, the pathognomonic lesion of scrub typhus was found only in 47.4% of the patients. Acute hepatitis was the most frequent complication encountered (33.2%). Majority (87.2%) of the patients improved and were successfully discharged. A total of 61 (31%) patients, out of the 196 included in the study, required admission to ICU. Mortality was more marked in patients suffering from shock, acute hepatitis, Acute kidney Injury, meningoencephalitis and myocarditis and Multiple Organ Dysfunction Syndrome (MODS) (p<0.05).Conclusion: Paediatric scrub typhus is quite common in the state of Odisha. Young age of presentation, presence of multi system involvement and delayed initiation of anti-rickettsial drugs due to delay in referral was also observed to be one of the poor prognostic factors.
机译：磨砂动卵藻是作为涉及主要器官系统的严重并发症的儿童常见的延长发热性疾病。它很容易治疗但治疗是关于早期识别严重疾病预测因子的挑战，这极大地影响了这一脆弱的人口中的结果。研究临床概况，分析这些患者的并发症和结果。材料和方法：这是一项基于医院的前瞻性观察研究。它在2017年10月至2019年10月的儿科医学院和医院内进行了Cuttack进行了薄饼。所有患有擦洗动脉毛虫的临床特征的儿童都受到免疫球蛋白M（IgM）磨砂膏试验。所有观察数据都是通过IBM统计包进行社会科学（SPSS）软件的分析，版本25.0和Chi-Square测试与P <0.05一样统计学意义。结果：从196个受试者中，大多数87（44.4％）发现在1-5岁的时候，大多数是男性（55.1％）。发烧普遍存在（100％）。 ESCHAR，仅在47.4％的患者中发现了擦洗毛巾的病例病变。急性肝炎是遇到的最常见的并发症（33.2％）。大多数（87.2％）的患者改善并成功排放。共有61名（31％）的患者，其中196名包括在该研究中，要求入院ICU。患有休克，急性肝炎，急性肾损伤，脑膜炎和心肌炎和多器官功能障碍综合征（MODS）的患者中的死亡率更为标记（MODS）（P <0.05）。结论：小儿磨砂动卵藻在Odisha状态非常常见。还观察到年轻的介绍性，由于转诊延迟的多系统参与和延迟引发的抗马车药物的发生是较差的预后因素之一。

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