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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Correlation of BCL-2 and Ki-67 Expression with Clinicopathological Parameters in Oral Squamous Cell Carcinoma
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Correlation of BCL-2 and Ki-67 Expression with Clinicopathological Parameters in Oral Squamous Cell Carcinoma

机译：口腔鳞状细胞癌临床病理参数的Bcl-2和Ki-67表达的相关性

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Oral Squamous Cell Carcinoma (OSCC) is the most common oral malignancy. Despite advancements in cancer therapeutics, early diagnosis, and prognosis of OSCC remains challenging. Evaluating clinicopathological characteristics, molecular biomarkers and their expression helps comprehend biological traits and tumour behaviour, which is crucial for early diagnosis and favorable prognosis.Aim: To evaluate the immunohistochemical expressions of B-cell Lymphoma 2 (BCL-2) and Ki-67 in OSCC and to correlate their molecular expressions with clinicopathological tumourigenic parameters.Materials and Methods: This cross-sectional study was conducted at Ramaiah Hospital, Bangalore, Karnataka, India, over a period of two years from June 2017 to May 2019 on 60 radical resection specimens of OSCC. After gross specimen examination, multiple representative tissue bits were obtained and subjected to Haematoxylin and Eosin (H&E) staining and staged. Immunohistochemical detection of BCL-2 and Ki-67 expression, semi-quantitative and intensity assessment of staining was performed. Data were analysed using statistical software R-version 4.0.1. The p≤0.05 was considered statistically significant.Results: The mean age was 57.88±13 years, and a large proportion were females (49, 81.67%). Mean BCL-2 and Ki-67 expression (%) were 24.58±11.29 and 29.5±17.21, respectively. The correlation of BCL-2 (p<0.001) and Ki-67 (p<0.001) expression with histological grades was statistically significant. The correlation of BCL-2 and Ki-67 expression with gross/clinicopathological features was not significant. A positive moderately strong significant correlation existed between BCL-2 and Ki-67 expression (p<0.001).Conclusion: BCL-2 and Ki-67 expression is independent of clinicopathological features of OSCC but is directly associated with increasing tumour grades. There is a direct moderately strong correlation between BCL-2 and Ki-67, indicating adverse clinical outcome. Their early identification is critical for effective therapeutic intervention and desirable prognosis.
机译：口腔鳞状细胞癌（OSCC）是最常见的口腔恶性肿瘤。尽管癌症治疗剂的进步，但OSCC的早期诊断和预后仍然挑战。评估临床病理特征，分子生物标志物及其表达有助于理解生物学性状和肿瘤行为，这对于早期诊断和有利预测至关重要。评价B细胞淋巴瘤2（BCL-2）和KI-67的免疫组织化学表达随着OSCC和将它们的分子表达与临床病理学肿瘤参数相关。在2017年6月至2019年5月，在2019年5月至2019年5月，在2019年6月至2019年5月在60次激进切除试样的两年内，在孟加拉国，班加罗拉，班加罗拉，班加罗拉，班加罗尔（Karnataka）的一段时间内进行了这种横断面研究OSCC。在总标本检查之后，获得多种代表性组织比特并进行氧毒素和曙红（H＆amp; e）染色和分阶段。进行了Bcl-2和Ki-67表达，半定量和染色强度评估的免疫组化检测。使用统计软件R-V5.0.1分析数据。 P≤0.05被认为是统计学意义。结果：平均年龄为57.88±13岁，女性大部分是女性（49,81.67％）。平均Bcl-2和Ki-67表达（％）分别为24.58±11.29和29.5±17.21。 Bcl-2（p <0.001）和Ki-67（p <0.001）表达与组织学等级的相关性具有统计学意义。 Bcl-2和Ki-67表达与总/临床病理学特征的相关性并不重要。 Bcl-2和Ki-67表达之间存在正激增的显着相关性（P <0.001）。结论：Bcl-2和Ki-67表达与OSCC的临床病理特征无关，但与增加肿瘤等级直接相关。 Bcl-2和Ki-67之间存在直接的正常相关性，表明临床结果不良。他们的早期鉴定对于有效的治疗干预和理想的预后至关重要。

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