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首页> 外文期刊>Journal of Clinical and Diagnostic Research >A Prospective Cohort Study Analysing 3-dimensional Conformal Radiotherapy and Salivary Glands Preserving Intensity Modulated Radiotherapy with/without Concomitant Cisplatin Chemotherapy in Head and Neck Malignancies
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A Prospective Cohort Study Analysing 3-dimensional Conformal Radiotherapy and Salivary Glands Preserving Intensity Modulated Radiotherapy with/without Concomitant Cisplatin Chemotherapy in Head and Neck Malignancies

机译：一种预期队列研究，分析三维保形放疗和唾液腺保存强度调节放疗与头部和颈部恶性肿瘤的伴随的顺铂化学疗法

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Most common toxicity of radiotherapy in head and neck malignancy patients is xerostomia. Xerostomia can be prevented by using salivary gland sparing Intensity Modulated Radiation Therapy (IMRT) technique.Aim: Comparing Dose Volume Histogram (DVH) of salivary glands in IMRT and 3-Dimensional Conformal Radiation Therapy (3DCRT) and evaluation of xerostomia, mucositis and dysphagia in both groups.Materials and Methods: The present study was a prospective cohort study in which 30 patients were selected. Patients of head and neck cancer reporting to Department of Radiation Oncology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, Karnataka, India were included. Duration of study was one year (January 2013 to December 2013). Fifteen patients treated with IMRT and 15 patients with 3DCRT to a dose of 60-70 Gy in 30-35 fractions, with or without concomitant cisplatin. DVH of salivary glands and incidence of xerostomia, mucositis and dysphagia was compared in both the groups. Patients were assessed during the course of radiotherapy and three months postradiotherapy.Results: Mean dose to contralateral parotid was 19.48 Gy in IMRT when compared to 47.31 Gy in 3DCRT. Mean dose to contralateral submandibular was 44.06Gy in IMRT when compared to 67.63 Gy in 3DCRT. At three, six and seven weeks there was a difference in number of patients having reduced severity of mucositis in IMRT when compared to 3DCRT. There was no significant difference in dysphagia between both groups at three, six and seven weeks and one month after the treatment. No significant difference in xerostomia between both the groups at seven week and one month after treatment. At three months after treatment the difference in xerostomia was significant between both groups (p<0.05) favouring IMRT. No tumour response benefit was seen with IMRT.Conclusion: Radiation dose received by salivary glands by IMRT was significantly less when compared to 3DCRT, thereby reducing the incidence, severity and duration of xerostomia. IMRT helps in reducing the severity and duration of dysphagia and mucositis in comparison to 3DCRT during radiotherapy of head and neck cancer.
机译：头部和颈部恶性肿瘤患者放射治疗的最常见毒性是Xerostomia。可以通过使用唾液腺备件强度调制的放射治疗（IMRT）技术来防止Xerostomia.aum：比较IMRT和三维保形放射治疗（3DCRT）中的唾液腺的剂量体积直方图（DVH）和Xerostomia，粘膜炎和吞咽症的评估在两组中。材料和方法：本研究是一项预期队列研究，其中30名患者被选中。包括头部和颈部癌症患者报告给放射肿瘤科，Vydehi医学科学研究所，班加罗尔，卡纳塔克邦，印度。学习持续时间为一年（2013年1月至2013年12月）。十五名患者用IMRT和15名3DCRT治疗的患者，剂量为60-70Gy，在30-35分级分，有或没有Cisplatin。在两组中比较了Xerostomia唾液腺和发病率的唾液腺和发病率。在放疗过程中评估了患者，并在3个月Postradiotherapy。结果：在3DCRT中的47.31Gy相比，IMRT的平均剂量为19.48 Gy。在3DCRT中的67.63 GY相比，IMRT的平均剂量为44.06gy。在三个，六到七周内，与3DCRT相比，IMRT在IMRT中严重程度严重程度的患者数量有所不同。两组在三个，六到七周和治疗后一个月内没有显着差异。七周和治疗后一个月的群体之间的Xerostomia没有显着差异。治疗三个月后，两组（P <0.05）之间的Xerostomia的差异是显着的。没有用IMRT.CONCRTS观察到肿瘤反应益处IMRT有助于降低吞咽困难和粘膜炎的严重程度和持续时间与3DCRT在头部和颈部癌症的放射治疗期间。

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