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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Effectiveness of Letrozole and Human Chorionic Gonadotropin Injection in Ovulation Induction: A Cohort Stud
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Effectiveness of Letrozole and Human Chorionic Gonadotropin Injection in Ovulation Induction: A Cohort Stud

机译：Letrozole和人绒毛膜促性腺激素在排卵诱导中注射的有效性：坐冠

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Ovulation stimulation followed by timed intercourse or Intrauterine Insemination (IUI) is widely used for treatment of anovulatory infertility.Aim: To compare the effectiveness of Letrozole (LE) alone versus LE and human chorionic gonadotropin injection in ovulation induction and pregnancy rates in women undergoing ovulation induction/follicular tracking in Enugu, Nigeria.Materials and Methods: The longitudinal cohort study was carried out in University of Nigeria Teaching Hospital and Livingston Specialist Gynaecological Hospital in Enugu, Nigeria. Study population were women coming for ovulation stimulation/follicular tracking. Ovulation was confirmed by ultrasound evidence of ovulation with a progesterone level of greater or equal to 25 nmol/L on day 21, positive pregnancy test/ultrasound detection of a gestational sac. Patients were consecutively assigned to group A or B. Group A received LE only for the induction while group B received 10000 IU of human chorionic gonadotropin injection in addition to LE. A total of 5 mg of LE was given daily from day 3 to day 7. The primary outcome measured was the number of ruptured/crenated follicles on either arm while the secondary outcomes were the number of Luteinised Unruptured Follicles (LUF) and pregnancy rates. The Statistical analysis was performed using the Statistical Package for the Social Sciences version 21.0 software (SPSS Inc., Chicago, IL, United States).Results: A total of 50 women were in each arm of the study. There was no significant difference in age and parity between the two arms. There was no significance difference between the period of infertility and the number of the previous cycles of ovulation stimulation. (p=0.444 and 0.526, respectively). Ovulation was significantly associated with HCG injection (p=0.001). However, there was no statistical significance between both arms regarding the number of LUF (p=0.216). HCG injection was significantly associated with pregnancy. Subjects who took HCG injection were over two times more likely to become pregnant than those without HCG injection (OR=2.488, 95% CI for OR=1.057-5.857, p=0.037).Conclusion: This study showed that both the ovulation rate and pregnancy rate are significantly improved when human chorionic gonadotrophin injection is given after ovarian stimulation.
机译：排卵刺激，然后是定时性交或宫内授精（IUI）广泛用于治疗逆转性不孕症。优雅：为了比较Lezole（Le）的有效性与Le和人绒毛膜促进剂中的排卵诱导和妊娠期患者患有排卵中的妊娠率Enugu，尼日利亚的诱导/滤窗跟踪。材料与方法：纵向队列研究在尼日利亚恩鲁省尼日利亚教学医院和Livingston专家妇科医院进行。学习人口是用于排卵刺激/滤窗追踪的女性。通过在第21天的孕酮水平的孕酮水平的超声波验证的超声证据证实排卵，妊娠囊的阳性妊娠试验/超声检测。患者连续分配给A或B组。除了LE之外，B组接受了10000例人绒毛膜促性腺激素注射液的诱导，仅供归纳。每天3日至第7天每天每天给出5毫克的le。测量的主要结果是臂上的破裂/愈合卵泡的数量，而二次结果是猪骨化的悬垂卵泡（Luf）和妊娠率的数量。使用社会科学版21.0软件（SPSS Inc.，Chicago，IL，美国）的统计包进行统计分析。结果：每项研究中共有50名女性。两只武器之间的年龄没有显着差异和平等。不孕症与排卵刺激的前一周期的数量之间没有显着性差异。 （P = 0.444和0.526）。排卵与HCG注射有显着相关（p = 0.001）。然而，对于Luf的数量（p = 0.216），两个武器之间没有统计学意义。 HCG注射与妊娠显着相关。服用HCG注射的受试者比没有HCG注射剂的可能性（OR = 2.488,95％CI，= 1.057-5.857，P = 0.037）。结论：该研究表明，该研究表明排卵率和排卵率均当卵巢刺激后，当人绒毛膜促性腺激素注射注射时，妊娠率显着提高。

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