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首页> 外文期刊>BMC Medical Genomics >MAD1L1 and TSNARE gene polymorphisms are associated with schizophrenia susceptibility in the Han Chinese population
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MAD1L1 and TSNARE gene polymorphisms are associated with schizophrenia susceptibility in the Han Chinese population

机译：Mad1L1和Tsnare基因多态性与汉族人口中的精神分裂症易感性有关

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Schizophrenia (SCZ) is a severe mental illness with high heritability. This study aimed to explore the correlation between MAD1L1, TSNARE polymorphisms and SCZ susceptibility. A total of 493 SCZ patients and 493 healthy controls were included. The genotypes of MAD1L1 and TSNARE polymorphisms were identified by Agena MassARRAY platform. Odds ratio (OR) and 95% confidence intervals (CIs) were tested via logistic regression analysis in multiple genetic models and different subgroups. We observed that AG genotype of rs1107592, AG genotype of rs4976976, and CA genotype of rs67756423 decreased the susceptibility to SCZ (p??0.05). Age stratification analysis showed that the TC genotype of rs12666575, AG genotype of rs1107592, and AG genotype of rs4976976 decreased the risk of SCZ individuals older than 36?years (p??0.05). In addition, the AG and AA genotype of rs4976976, the CA genotype of rs67756423 were associated with a lower risk of SCZ in males (p??0.05). In females, the TT genotype of rs12666575 in recessive model, the AG and AA-AG genotype of rs1107592 in heterozygote and dominant model, could reduce the susceptibility to SCZ (p??0.05). However, no significant association was found after Bonferroni correction. Our results suggest that MAD1L1 and TSNARE genetic polymorphisms exert a protective role in the risk of SCZ. These findings provide evidence that MAD1L1 and TSNARE may serve as potential biomarkers of SCZ. However, a replication experiment in a cohort with large sample size are required to confirm our findings. Trial registration Not applicable.
机译：精神分裂症（SCZ）是一种严重的精神疾病，具有高遗传性。本研究旨在探讨Mad1L1，Tsnare多态性与SCZ易感性之间的相关性。共有493名SCZ患者和493名健康对照。 Gena Massarray平台鉴定了Mad1L1和Tsnare多态性的基因型。通过多种遗传模型和不同亚组的逻辑回归分析测试差距比（或）和95％置信区间（CIs）。我们观察到RS1107592，AG基因型的AG基因型，RS4976976和RS67756423的CA基因型降低了对SCZ的易感性（P？＆ 0.05）。年龄分层分析表明，RS1107592的TR12666575，AG基因型的TC基因型，AG基因型为RS4976976的AG基因型降低了SCZ个体的风险超过36岁？岁（P？＆ 0.05）。此外，RS4976976的AG和AA基因型，RS67756423的CA基因型与雄性SCZ的风险较低有关（P？＆ 0.05）。在雌性中，在隐性模型中，RS12666575的TT基因型，杂合子和显性模型中的RS1107592的AG和AA-AG基因型，可以降低对SCZ的易感性（P？＆ 0.05）。但是，在Bonferroni校正之后没有发现任何重要的关联。我们的研究结果表明，Mad1L1和Tsnare遗传多态性在SCZ的风险中发挥了保护作用。这些调查结果提供了Mad1L1和Tsnare的证据可以作为SCZ的潜在生物标志物。然而，需要具有大样本大小的群组中的复制实验来确认我们的研究结果。试验登记不适用。

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