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首页> 外文期刊>BMC Ophthalmology >Peripapillary vessel density measurement of quadrant and clock-hour sectors in primary angle closure glaucoma using optical coherence tomography angiography
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Peripapillary vessel density measurement of quadrant and clock-hour sectors in primary angle closure glaucoma using optical coherence tomography angiography

机译：使用光学相干断层造影血管造影的象限和时钟小时扇区的围裤和时钟小时扇区的围网血管密度测量

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The purpose of this study was to investigate diagnostic ability of peripapillary vessel density of primary angle closure glaucoma (PACG) eyes in quadrant and clock-hour sectors by optical coherence tomography angiography (OCTA). This was a cross-sectional study on forty-one PACG patients (41eyes) and twenty-seven healthy subjects (27 eyes). All subjects underwent OCTA (DRI OCT Triton; Topcon Corporation, Tokyo, Japan) and peripapillary retinal nerve fiber layer (RNFL) thickness imaging with swept-source optical coherence tomography (OCT). The peripapillary vessel density of quadrant and clock-hour sectors was quantified by imageJ software. The diagnostic capability of OCTA and OCT parameters was evaluated by the areas under the receiver operating characteristics curves (AUCs). Pearson correlation analysis or Spearman correlation test was used to evaluate the correlation between vessel density parameters and related factors. Compared with the control group, the peripapillary vessel density of glaucomatous group was lower to different degrees in the four quadrants and each clock-hour sectors, and vessel density reduced most at 7 o’clock. The difference between the diagnostic ability of peripapillary vessel density and peripapillary RNFL thickness was not statistically significant, except 4 o’clock and inferior quadrant. The inferior quadrant peripapillary vessel density had the best diagnostic value (AUC0.969), followed by the 7 o’clock vessel density (AUC0.964), average vessel density (AUC0.939) and the 7 o’clock RNFL thickness (AUC0.919). The average peripapillary vessel density was correlated with average RNFL and visual field (VF) mean deviation (P ?0.001). In PACG, the diagnostic ability of the peripapillary vessel density is equivalent to the peripapillary RNFL thickness. Understanding spatial characteristics of the peripapillary vessel density in PACG may be helpful for clinical diagnosis and monitoring the progress of diseases.
机译：本研究的目的是调查通过光学相干断层造影血管造影（OctA）在象限和时钟小时扇区中探讨围角闭合青光眼（PACG）眼睛的静脉血管密度的诊断能力。这是对四十一豆类患者（41eyes）和二十七名健康受试者（27只眼）的横截面研究。所有受试者都经历了Octa（DRI OCT TRITON; TOPCON公司，东京，日本）和围爪植物视网膜神经纤维层（RNFL）厚度成像与扫描源光学相干断层扫描（OCT）。通过imagej软件量化象限和时钟小时扇区的围类血管血管密度。 OctA和OCT参数的诊断能力由接收器操作特性曲线（AUCS）下的区域评估。 Pearson相关性分析或Spearman相关试验用于评估容器密度参数和相关因素之间的相关性。与对照组相比，四象限和每个时钟小时扇区的胶囊血管血管血管密度低至不同程度，并且每钟血管密度最低减少。除4点和劣质象限之外，围毛绒血管密度和围毛绒RNFL厚度的诊断能力之间的差异在统计学上没有统计学意义。次级象限的百百年围绕血管密度具有最佳的诊断值（AUC0.969），其次是7点钟血管密度（AUC0.964），平均血管密度（AUC0.939）和7点钟rNFL厚度（AUC0 .919）。平均百百百年血管密度与平均RNFL和视野（VF）平均偏差相关（P <0.001）。在PACG中，围毛绒血管密度的诊断能力相当于围产物RNFL厚度。了解PACG中围毛血管密度的空间特征可能有助于临床诊断和监测疾病的进程。

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