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首页> 外文期刊>BMC Neuroscience >The disrupted topological properties of structural networks showed recovery in ischemic stroke patients: a longitudinal design study
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The disrupted topological properties of structural networks showed recovery in ischemic stroke patients: a longitudinal design study

机译：破坏结构网络的拓扑特性显示出缺血性卒中患者的恢复：纵向设计研究

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Stroke is one of the leading causes of substantial disability worldwide. Previous studies have shown brain functional and structural alterations in adults with stroke. However, few studies have examined the longitudinal reorganization in whole-brain structural networks in stroke. Here, we applied graph theoretical analysis to investigate the longitudinal topological organization of white matter networks in 20 ischemic stroke patients with a one-month interval between two timepoints. Two sets of clinical scores, Fugl-Meyer motor assessment (FMA) and neurological deficit scores (NDS), were assessed for all patients on the day the image data were collected. The stroke patients exhibited significant increases in FMA scores and significant reductions in DNS between the two timepoints. All groups exhibited small-world organization (σ 1) in the brain structural network, including a high clustering coefficient (γ 1) and a low normalized characteristic path length (λ ≈ 1). However, compared to healthy controls, stroke patients showed significant decrease in nodal characteristics at the first timepoint, primarily in the right supplementary motor area, right middle temporal gyrus, right inferior parietal lobe, right postcentral gyrus and left posterior cingulate gyrus. Longitudinal results demonstrated that altered nodal characteristics were partially restored one month later. Additionally, significant correlations between the nodal characteristics of the right supplementary motor area and the clinical scale scores (FMA and NDS) were observed in stroke patients. Similar behavioral-neuroimaging correlations were found in the right inferior parietal lobe. Altered topological properties may be an effect of stroke, which can be modulated during recovery. The longitudinal results and the neuroimaging-behavioral relationship may provide information for understanding brain recovery from stroke. Future studies should detect whether observed changes in structural topological properties can predict the recovery of daily cognitive function in stroke.
机译：中风是全世界大量残疾的主要原因之一。以前的研究表明了脑中风中的脑功能和结构改变。然而，很少有研究已经检查了中风中全脑结构网络中的纵向重组。在这里，我们应用了图形理论分析，以调查20个缺血性脑卒中患者的白质型血清网络的纵拓组织，在两个时间点之间的一个月间隔。两组临床评分，Fugl-Meyer Motor评估（FMA）和神经缺陷分数（NDS），对所有患者进行了评估了当天收集的所有患者。中风患者表现出FMA评分的显着增加，并且在两个时间点之间的DNS中显着减少。所有组在脑结构网络中展现出小世界组织（σ＆ 1），包括高聚类系数（γ＆ 1）和低归一化特征路径长度（λ≈1）。然而，与健康对照相比，中风患者在第一个时光的节点特征上显示出显着降低，主要是在右辅助电动机面积，右中间颞克鲁斯，右下榫叶，右后和左侧铰接旋转。纵向结果表明，一个月后，改变的节点特征是部分恢复的。另外，在中风患者中观察到右辅助电动机面积的节点特征与临床比分（FMA和NDS）之间的显着相关性。在右下方叶片中发现了类似的行为 - 神经影像元相关性。改变的拓扑性质可以是中风的效果，其可以在恢复期间调节。纵向结果和神经影像行为关系可以提供了解从中风中脑恢复的信息。未来的研究应检测是否观察到结构拓扑性质的变化是否可以预测中风中日常认知功能的恢复。

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