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首页> 外文期刊>Artificial cells, nanomedicine, and biotechnology. >Tripterine and all-trans retinoic acid (ATRA) – loaded lipid-polymer hybrid nanoparticles for synergistic anti-arthritic therapy against inflammatory arthritis
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Tripterine and all-trans retinoic acid (ATRA) – loaded lipid-polymer hybrid nanoparticles for synergistic anti-arthritic therapy against inflammatory arthritis

机译：泰特林和全反式视黄酸（ATRA） - 负载脂质 - 聚合物杂交纳米粒子，用于抗炎性关节炎的协同抗关节炎治疗

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Arthritis of joints remains a hard-to-treat disease due to the low drug exposure to the articular cavity. Present study was intended to develop a Tripterine (TRI) and all-trans retinoic acid (ATRA)-loaded lipid-polymer hybrid nanoparticles (ATLP) for enhanced antiarthritic efficacy in arthritis conditions. We have showed that two drugs could be loaded with high loading capacity and control the release kinetics in a pH-responsive manner. The ATLP showed strong inhibitory effects on the expressions of TNF-α, IL-6 and IL-1β in lipopolysaccharide (LPS)-stimulated RAW264.7 cells at the in vitro conditions. Compared to individual drugs (TRI and ATRA), ATLP significantly reduced the paw thickness exhibiting potent inhibition of inflammation. Consistently, ATLP resulted in lowest clinical score compared to that of individual drug indicating the remarkable improvement in the recession of inflammation. We have clearly demonstrated that the nanoparticulate based co-delivery of drugs could abolish the adverse effects of free drug as indicated by the body weight changes. Importantly, ATLP resulted in significant reduction of mRNA of TNF-α, IL-6, IFN-? and IL-17 compared to either free drugs or CIA mice. Overall, ATLP represent a promising therapeutic strategy for the treatment of arthritis conditions.
机译：由于药物暴露于关节腔的低药物暴露，关节关节炎仍然是一种难以治疗的疾病。目前的研究旨在开发赛替替昔单抗（ATRA） - 加载的脂质 - 聚合物杂化纳米颗粒（ATLP），用于增强关节炎条件下的抗炎效果。我们已经表明，两种药物可以用高负载能力加载，并以pH响应方式控制释放动力学。 ATLP对在体外条件下对脂多糖（LPS）拟计的RNF-α，IL-6和IL-1β中TNF-α，IL-6和IL-1β的表达的强烈抑制作用。与个体药物（TRI和ATRA）相比，ATLP显着降低了表现出炎症有效抑制的爪子厚度。始终如一地，与个体药物相比，ATLP导致临床分数最低，表明炎症衰退的衰退显着改善。我们已经清楚地证明，基于纳米颗粒的药物的共递送可以通过体重变化所示，取消自由药物的不良反应。重要的是，ATLP导致TNF-α，IL-6，IFN的mRNA显着降低 - ？和IL-17相比，与免费药物或CIA小鼠相比。总体而言，ATLP代表了治疗关节炎条件的有希望的治疗策略。

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