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首页> 外文期刊>Indian Journal of Critical Care Medicine >Direct Measurement of Creatinine Clearance over a Short Interval in Intensive Care Settings
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Direct Measurement of Creatinine Clearance over a Short Interval in Intensive Care Settings

机译：在密集护理环境中直接测量肌酐清除的短暂间隔

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Background:The definition of acute kidney injury (AKI), based on serum creatinine and urine output, bears significant limitations in intensive care units (ICUs). Serum creatinine has significant lag-time as it needs to be accumulated and stabilized at a new level whereas urine output is affected by diuresis, antidiuresis, and antinatriuresis. Direct measurement of creatinine clearance (CrCl direct = urine creatinine × urine flow rate/serum creatinine) over a short interval (3-6 hours) was explored to identify patients with AKI.Materials and methods:We reanalyzed a previous published dataset. We included 11 patients who had serial daily urine collections over 0 to 3 days of stay in ICU and baseline (day -1) serum creatinine levels.Result:The ratio of CrCl direct on day 0 to baseline creatinine clearance predicted the progression of AKI over the subsequent 1 to 3 days of ICU stay [area under receiver operating characteristic curve = 0.933 and 95% confidence interval (CI) = 0.780-1.000].Discussion:CrCl direct over a short interval may be an alternative marker of kidney function. Future studies may explore its use to identify patients with AKI who may benefit from early renal replacement therapy.How to cite this article:Law LSC, Lo EAG, Yeoh SF. Direct Measurement of Creatinine Clearance over a Short Interval in Intensive Care Settings. Indian J Crit Care Med 2021;25(7):800-802.Copyright ? 2021; Jaypee Brothers Medical Publishers (P) Ltd.
机译：背景：基于血清肌酐和尿量输出的急性肾损伤（AKI）的定义具有重症监护单位（ICU）的显着限制。血清肌酐具有显着的滞后时间，因为它需要在新的水平累积和稳定，而尿量产量受DIURESIS，Altidiuresis和AntinatriureSis的影响。探讨了在短暂间隔内（3-6小时）的肌酐清除（CRCL Digine =尿肌酐×尿肉毒素）的直接测量，以鉴定Aki.Materials和方法的患者：我们重新分析了一个上一个公开的数据集。在ICU和基线（Day-1）血清肌酐水平中，我们包括11名患者患有连续日常尿液收集的患者。结果：第0天至基线肌酐清除的CRCL直接的比例预测AKI的进展随后的ICU停留[接收器下的区域的1至3天，操作特征曲线= 0.933和95％置信区间（CI）= 0.780-1.000。Discussion：CRCL指导在短暂间隔中可能是肾功能的替代标记。未来的研究可以探索它用于识别可能从早期肾替代治疗中受益的AKI患者。为了引用本文：法律LSC，LO EAG，Yeoh SF。在重症监护环境中直接测量肌酐清除的短暂间隔。印度j crit care med 2021; 25（7）：800-802.copyright？ 2021; Jaypee Brothers Medical Publishers（P）有限公司

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