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首页> 外文期刊>Indian Journal of Critical Care Medicine >Epidemiology and Prognostic Utility of Cellular Components of Hematological System in Sepsis
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Epidemiology and Prognostic Utility of Cellular Components of Hematological System in Sepsis

机译：脓毒症血液系统细胞组分的流行病学和预后效用

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Background:Data are lacking on the role of cellular components of hematological system as biomarkers for prognosis of sepsis. We planned to identify if these parameters measured at admission to ICU and at 72 hours can be useful as prognostic marker in septic critically ill patients.Materials and methods:In this prospective observational study, 130 adult patients with sepsis were recruited. Various hematological study parameters (total, differential, and absolute leukocyte count, platelet count, platelet distribution width, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio) were noted at day 1 and day 3 of admission. Primary outcome was 28-day mortality, and secondary outcomes were duration of mechanical ventilation, vasopressor requirement, ICU length of stay, and requirement of renal replacement therapy. The variables were compared between two groups and using binary regression model and were evaluated as prognostic markers for 28-day mortality.Results:Data from n = 129 were analyzed. At day-28, n = 58 (44.96%) patients survived. Baseline and demographic parameters were comparable between survivors and nonsurvivors. Admission Sequential Organ Failure Assessment score was more in nonsurvivors than survivors [8 (6-8) vs 6 (4-8); p = 0.002]. In nonsurvivors, monocyte, lymphocyte, basophil, eosinophil, and platelet count were significantly less at day 1 and lymphocyte, eosinophil, basophil and platelet count were significantly less at day 3. NLR and PLR at day 3 were significantly more in nonsurvivors. On logistic regression analysis, age, thrombocytopenia on day 1, and low eosinophil count on day 3 predicted 28-day mortality (p = 0.006, p = 0.02, and p = 0.04, respectively).Conclusion:Thrombocytopenia on day 1 and eosinopenia on day 3 may predict 28-day mortality in sepsis.How to cite this article:Sinha H, Maitra S, Anand RK, Aggarwal R, Rewari V, Subramaniam R, et al. Epidemiology and Prognostic Utility of Cellular Components of Hematological System in Sepsis. Indian J Crit Care Med 2021;25(6):660-667.Copyright ? 2021; Jaypee Brothers Medical Publishers (P) Ltd.
机译：背景：血液系统细胞组分作为败血症预后的生物标志物的作用缺乏数据。我们计划确定是否在入院中测量的这些参数和72小时，可用作脓毒症批判性患者的预后标志物。材料和方法：在这项前瞻性观察研究中，招募了130例患有败血症患者。在入院第1天和第3天注意到各种血液学研究参数（总，差异和绝对白细胞计数，血小板计数，血小板分布宽度，中性粒细胞与血小板到淋巴细胞比。主要结果是28天的死亡率，二次结果是机械通气，血管加压器要求，ICU住院时间的持续时间，以及肾脏替代疗法的要求。比较两组和使用二进制回归模型的变量，并评估为28天死亡率的预后标志物。结果：分析来自n = 129的数据。在第28天，n = 58（44.96％）患者存活。基线和人口统计学参数在幸存者和非对抗者之间是可比的。入场顺序器官失败评估比幸存者更加在非幸存者[8（6-8）vs 6（4-8）; p = 0.002]。在第1天的第1天，第3天，在第1天，淋巴细胞，嗜酸性粒细胞，嗜碱性粒细胞和血小板计数明显少3天，在不少于淋巴细胞，嗜酸性粒细胞，嗜碱性粒细胞和血小板计数。关于逻辑回归分析，第1天的年龄，血小板减少症，以及第3天的低嗜酸性粒细胞计数预测28天死亡率（p = 0.006，p = 0.02，分别为p = 0.04）。结论：第1天和血管发育病症和嗜血孔第3天可以预测败血症的28天死亡率。如何引用本文：Sinha H，Maitra S，Anand RK，Aggarwal R，Rewari V，Subramaniam R等人。败血症血液系统细胞成分的流行病学及预后效用。印度j crit care med 2021; 25（6）：660-667.Copyright？ 2021; Jaypee Brothers Medical Publishers（P）有限公司

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