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Keloidal pathophysiology: Current notions

机译：瘢痕疙瘩病理生理学：当前观念

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Introduction: Keloids are pathological scars that are notorious for their chronic and relentless invasion into adjacent healthy skin, with commonly seen post-therapeutic recurrence after monotherapies. Methods: An English literature review on keloid pathophysiology was performed by searching the PubMed, Embase and Web of Science databases, to find out the up-to-date relevant articles. The level of evidence was evaluated based on the included studies with the highest level of evidence first. Results: Keloid morphology, signs, symptoms and the histopathological changes that occur in the local cells and extracellular matrix components are described. The theories on the pathophysiology of keloidogenesis that have been proposed to date are also covered; these include endocrinological, nutritional, vascular, and autoimmunological factors. In addition, we describe the local mechanical forces (and the mechanosignalling pathways by which these forces shape keloid cell activities) that promote keloid formation and determine the direction of invasion of keloids and the body sites that are prone to them. Conclusion: A better understanding of this pathological entity, particularly its mechanobiology, will aid the development of new diagnostic and therapeutic strategies for use in the clinic to prevent, reduce or even reverse the growth of this pathological scar.
机译：简介：Keloids是病态疤痕，对其慢性和无情的侵袭令人讨厌的是邻近的健康皮肤，在单一医疗后常见的治疗后复发。方法：通过搜索PubMed，Embase和Science和Web，来了解瘢痕疙瘩病理物理学的英语文献综述，以了解最新的相关文章。基于所包含的研究，评估证据水平，首先具有最高级别的证据。结果：描述了在局部细胞和细胞外基质组分中发生的瘢痕疙瘩形态，迹象，症状和组织病理学变化。还涵盖了已经提出的kelopoItobis的病理生理学理论也被覆盖;这些包括内分泌，营养，血管和自身免疫因素。此外，我们描述了促进瘢痕疙瘩形成并确定瘢痕疙瘩的侵袭方向和易于瘢痕疙瘩的机械锁定途径。结论：更好地了解这种病理实体，特别是其力学生物学，将有助于开发新的诊断和治疗策略用于诊所用于预防，减少甚至逆转这种病理瘢痕的生长。

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