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Improvement in the risk assessment of oral leukoplakia through morphology-related copy number analysis

机译：通过形态学相关拷贝数分析改善口服白斑风险评估

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Oral leukoplakia is the most common type of oral potentially malignant disorders and considered a precursor lesion to oral squamous cell carcinoma. However, a predictor of oral leukoplakia prognosis has not yet been identified. We investigated whether copy number alteration patterns may effectively predict the prognostic outcomes of oral leukoplakia using routinely processed paraffin sections. Comparison of copy number alteration patterns between oral leukoplakia with hyperplasia (HOL, n =22) and dysplasia (DOL, n =21) showed that oral leukoplakia with dysplasia had a higher copy number alteration rate (86%) than oral leukoplakia with hyperplasia (46%). Oral leukoplakia with dysplasia exhibited a wider range of genomic variations across all chromosomes compared with oral leukoplakia with hyperplasia. We also examined a retrospective cohort of 477 patients with oral leukoplakia with hyperplasia with detailed follow-up information. The malignant transformation (MT, n =19) and leukoplakia recurrence (LR, n =253) groups had higher frequencies of aneuploidy events and copy number loss rate than the free of disease (FD, n =205) group. Together, our results revealed the association between the degree of copy number alterations and the histological grade of oral leukoplakia and demonstrated that copy number alteration may be effective for prognosis prediction in oral leukoplakia patients with hyperplasia.
机译：口服卵泡是最常见的口腔口腔潜在恶性疾病，并考虑口腔鳞状细胞癌的前体病变。然而，尚未确定口服白斑预后的预测因子。我们调查了复制次数改变模式是否可以有效地预测使用常规加工的石蜡部分使用常规加工的口服白斑的预后结果。口服白血病（HOL，N = 22）和发育不良（DOL，N = 21）之间的拷贝数改变模式的比较显示，口服白血病与发育不良的拷贝数改变率高（86％），而不是口腔白血病（ 46％）。与发育不良的口腔白细胞表现出均有更广泛的染色体的基因组变异，与口腔白细胞相比具有增生。我们还研究了一个备注的477名口腔白斑患者的回顾队列，具有具有详细的后续信息的增生。恶性转化（MT，N = 19）和白斑复发（LR，N = 253）组具有比无疾病（FD，N = 205）组的无倍差事件和拷贝数损失率更高的频率。我们的结果揭示了拷贝数改变程度与口服白斑的组织学等级之间的关联，并证明拷贝数改变可能是口服白血交患者的预后预测。

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