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首页> 外文期刊>Substance Abuse Treatment, Prevention, and Policy >Changes in substance use during outpatient treatment for substance use disorders: a prospective Norwegian cohort study from 2016 to 2020
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Changes in substance use during outpatient treatment for substance use disorders: a prospective Norwegian cohort study from 2016 to 2020

机译：物质使用疾病门诊治疗过程中使用的物质使用变化：2016年至2020年的预期挪威队列研究

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Continuous use of amphetamines, alcohol, benzodiazepines, cannabis, cocaine, or opioids contributes to health impairments, increased morbidity, and overdose deaths among patients with substance use disorders (SUDs). This study evaluates the impact of inpatient detoxification, injecting substance use, age, and gender on substance use over time among patients undergoing outpatient SUD treatment. We used data from a cohort of SUD patients in Norway obtained from health assessments of self-reported substance use and sociodemographic and clinical factors. A total of 881 substance use measurements, including substances and frequency of use, were assessed for 708 SUD patients in 2016–2020. Of those, 171 patients provided two or more substance use measurements. The total substance use was calculated, creating a substance use severity index (SUSI), ranging from zero (no use) to one (daily use of all substances). We defined baseline as the first substance use measurement when the measurements were listed chronologically. Time was defined as years from baseline. We used a linear mixed model to analyze the SUSI at baseline and over time, and its associations with inpatient detoxification, injecting substance use, gender, and age, presented with coefficients and 95% confidence intervals (CI). No longitudinal changes in the SUSI were found compared with baseline (change in SUSI (cSUSI): 0.04, 95% CI: ??0.05;0.13, p?=?0.397). Likewise, “inpatient detoxification” was not associated with changes in the SUSI compared with “no inpatient detoxification” (cSUSI: 0.00, 95% CI: ??0.04;0.04, p?=?0.952). However, injecting substances were associated with a higher SUSI than not injecting substances at baseline (difference in SUSI: 0.19, 95% CI: 0.16;0.21, p?=??0.001), and starting to inject substances was associated with increasing SUSI over time compared with not starting to inject substances (cSUSI: 0.11, 95% CI: 0.07;0.15, p?=??0.001). Gender was not significantly associated with changes in the SUSI (cSUSI: ??0.04, 95% CI: ??0.07;0.00, p?=?0.052), while patients over 60?years of age had a lower SUSI than those under the age of 30 at baseline (difference in SUSI: ??0.08, 95% CI: ??0.14;??0.01, p?=?0.018), with no change over time (cSUSI: ??0.05, 95% CI: ??0.16;0.05, p?=?0.297). The present study demonstrates that inpatient detoxification was not associated with substance use changes over time for patients undergoing outpatient SUD treatment. Otherwise, injecting substance use was a particular risk factor for a high level of substance use. Future research needs to evaluate the impact of other treatment approaches on substance use, ideally in randomized controlled trials.
机译：连续使用安非胺，酒精，苯二氮卓，大麻，可卡因或阿片类药物有助于健康障碍，发病率增加，并且物质使用障碍患者的过量死亡和过量死亡。本研究评估了在进行门诊泡沫治疗的患者中随着时间的推移对物质使用的影响，注射物质使用，年龄和性别的影响。我们使用从挪威群体群体的数据从自我报告的物质使用和社会碘目和临床因素的健康评估中获得。在2016 - 2020年708例抑菌患者中评估了总共881种物质使用测量，包括物质和使用频率。其中，171名患者提供了两种或多种物质使用测量。计算总物质使用，产生物质使用严重程度指数（SUSI），从零（无用）到一个（每日使用所有物质）。我们定义基线作为第一种物质使用测量时测量时间按顺序列出。时间是从基线的几年定义的。我们使用了线性混合模型来分析了基线的苏伊，而随着时间的推移，其与住院解毒，注射物质使用，性别和年龄的关联，呈现系数和95％置信区间（CI）。与基线相比，没有发现Susi的纵向变化（Susi（CSUSI）的变化：0.04,95％CI：0.05; 0.13，P？= 0.397）。同样，与“无住院性排毒”（CSUSI：0.00,95％CI：0.04，P≤0.04，p≤0.04，p≤0.04，p≤0.04，p≤0.04，p≤0.04，p≤0.04，p≤0.04，p≤0.04，p≤0.04，p≤0.04，p≤0.04，p≤0.04，p≤0.04）。然而，注射物质与更高的Susi相关，而不是在基线下注射物质（Susi：0.19,95％：0.16; 0.21，p≤≤0.01.01，p？=β+，并开始注入物质与增加相关Susi随着时间的推移与未开始注射物质（CSUSI：0.11,95％CI：0.07; 0.15，P？=Δ0.001）。性别与Susi的变化没有显着相关（CSUSI：0.04,95％CI：0.07; 0.00，P？= 0.052），而60多岁以上的患者的血清率低于在基线30年代（Susi的差异：0.08,95％Ci：?? 0.14; ?? ?? 0.01，p？= 0.018），没有变化随时间（Csusi：?? 0.05,95％CI：？ ？0.16; 0.05，p？= 0.297）。本研究表明，在进行门诊泡沫治疗的患者随着时间的推移随着时间的推移没有与物质使用变化有关。否则，注射物质使用是高水平的物质使用的特定危险因素。未来的研究需要评估其他治疗方法对物质使用的影响，理想地在随机对照试验中。

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