• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Substance Abuse Treatment, Prevention, and Policy >Exploring the effectiveness of dextroamphetamine for the treatment of stimulant use disorder:?a qualitative study?with patients receiving injectable opioid agonist treatment
【24h】

Exploring the effectiveness of dextroamphetamine for the treatment of stimulant use disorder:?a qualitative study?with patients receiving injectable opioid agonist treatment

机译：探索葡聚糖对兴奋剂使用障碍治疗的有效性：？与接受可注射阿片激动剂治疗的患者进行定性研究？

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A high proportion of people receiving both oral and injectable opioid agonist treatment report concurrent use of stimulants (i.e. cocaine and or amphetamines), which has been associated with higher rates of continued illicit opioid use and treatment dropout. A recent randomized controlled trial demonstrated the effectiveness of dextroamphetamine (a prescribed stimulant) at reducing craving for and use of cocaine among patients receiving injectable opioid agonist treatment. Following this evidence, dextroamphetamine has been prescribed to patients with stimulant use disorder at a clinic in Vancouver. This study investigates perceptions of the effectiveness of dextroamphetamine from the perspective of these patients. Data were collected using small focus groups and one-on-one interviews with patients who were currently or formerly receiving dextroamphetamine (n?=?20). Thematic analysis was conducted using an iterative approach, moving between data collection and analysis to search for patterns in the data across transcripts. This process led to the defining and naming of three central themes responding to the research question. Participants reported a range of stimulant use types, including cocaine (n?=?8), methamphetamine (n?=?8), or both (n?=?4). Three central themes were identified as relating to participants’ perceptions of the effectiveness of the medication: 1) achieving a substitution effect (i.e. extent to which dextroamphetamine provided a substitution for the effect they received from use of illicit stimulants); 2) Reaching a preferred dose (i.e. speed of titration and effect of the dose received); and 3) Ease of medication access (i.e. preference for take home doses (i.e. carries) vs. medication integrated into care at the clinic). In the context of continued investigation of pharmacological treatments for stimulant use disorder, the present study has highlighted how the study of clinical outcomes could be extended to account for factors that contribute to perceptions of effectiveness from the perspective of patients. In practice, elements of treatment delivery (e.g. dosing and dispensation protocols) can be adjusted to allow for various scenarios (e.g. on site vs. take home dosing) by which dextroamphetamine and other pharmacological stimulants could be implemented to provide “effective” treatment for people with a wide range of treatment goals and needs.
机译：高比例的人接受口腔和可注射的阿片类药物治疗报告同时使用兴奋剂（即可卡因和或或amphetamines），这与持续的非法表阿片类药物和治疗辍学率较高。最近的随机对照试验证明了葡聚糖（一种规定兴奋剂）在接受可注射阿片激动剂治疗的患者中减少可卡因的渴望和使用可卡因的有效性。在此证据之后，葡聚糖戊胺已在温哥华诊所的兴奋剂使用障碍患者方案。本研究研究了从这些患者的角度看着葡聚糖的有效性的看法。使用小型焦点小组和一对一访谈，与目前或以前接受葡聚糖（n？= 20）的患者进行一次采访。使用迭代方法进行主题分析，在数据收集和分析之间移动以搜索跨越成绩单数据中的模式。这种过程导致了三个中央主题的定义和命名响应了研究问题。参与者报告了一系列兴奋剂使用类型，包括可卡因（N？=α8），甲基苯丙胺（N？=？8），或两者（n？=？4）。鉴定了三个中央主题与参与者对药物有效性的看法有关：1）实现替代效应（即葡聚糖的程度提供了从使用非法兴奋剂的使用效果）; 2）达到优选的剂量（即滴定的速度和剂量的效果）; 3）易于用药物进入（即偏爱Home剂量（即携带）与药物在诊所融入护理中）。在继续调查兴奋剂使用障碍的药理治疗的背景下，本研究强调了如何扩展临床结果的研究，以考虑患者视角下有助于效力的因素。在实践中，可以调节治疗递送（例如剂量和分配方案）的元素，以允许各种场景（例如，在现场与家用剂量），通过该方案可以实施葡聚糖和其他药理学兴奋剂以提供“有效”治疗具有广泛的治疗目标和需求。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号