• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pulmonary Circulation >Effects of macitentan and tadalafil monotherapy or their combination on the right ventricle and plasma metabolites in pulmonary hypertensive rats
【24h】

Effects of macitentan and tadalafil monotherapy or their combination on the right ventricle and plasma metabolites in pulmonary hypertensive rats

机译：Macitentan和Tadalafil Mootherapy的影响或它们对肺高血压大鼠右心室和血浆代谢物的影响

获取原文
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Pulmonary arterial hypertension is a severe respiratory disease characterized by pulmonary artery remodeling. RV dysfunction and dysregulated circulating metabolomics are associated with adverse outcomes in pulmonary arterial hypertension. We investigated effects of tadalafil and macitentan alone or in combination on the RV and plasma metabolomics in SuHx and PAB models. For SuHx model, rats were injected with SU5416 and exposed to hypoxia for three weeks and then were returned to normoxia and treated with either tadalafil (10?mg/kg in chow) or macitentan (10?mg/kg in chow) or their combination (both 10?mg/kg in chow) for two weeks. For PAB model, rats were subjected to either sham or PAB surgery for three weeks and treated with above-mentioned drugs from week 1 to week 3. Following terminal echocardiographic and hemodynamic measurements, tissue samples were collected for metabolomic, histological and gene expression analysis. Both SuHx and PAB rats developed RV remodeling/dysfunction with severe and mild plasma metabolomic alterations, respectively. In SuHx rats, tadalafil and macitentan alone or in combination improved RV remodeling/function with the effects of macitentan and combination therapy being superior to tadalafil. All therapies similarly attenuated SuHx-induced changes in plasma metabolomics. In PAB rats, only macitentan improved RV remodeling/function, while only tadalafil attenuated PAB-induced changes in plasma metabolomics.
机译：肺动脉高压是一种严重的呼吸道疾病，其特征在于肺动脉重塑。 RV功能障碍和失调的循环代谢组学与肺动脉高压的不良结果有关。我们在SUHX和PAB模型中单独或组合研究了塔达拉非尔和甲基锡和癌锡的影响。对于SUHX模型，大鼠用SU5416注射并暴露于缺氧三周，然后返回常氧，并用塔达拉非（10×Mg / kg）或Chow incistan（10×mg / kg）或它们的组合处理（含10毫克/千克的含量）两周。对于PAB模型，大鼠进行假或PAB手术3周，并在第1周至第3周，用上述药物处理3.在末端超声心动图和血液动力学测量后，收集组织样品进行代谢物，组织学和基因表达分析。 SUHX和PAB大鼠分别发育了RV重塑/功能障碍，分别具有严重和轻度血浆代谢物改变。在SUHX大鼠，单独或组合改善RV重塑/功能的达拉非毒药和Macitentan的效果和组合治疗优于Tadalafil。所有疗法同样衰减的SUHX诱导的血浆代谢组学变化。在PAB大鼠中，只有Macitentan改善了RV重塑/功能，而只有塔达拉非衰减的血浆代谢组合的诱导的变化。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号