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首页> 外文期刊>Therapeutic advances in drug safety. >Fansidar drug induces cytotoxicity in some vital tissues in a rat model: combination defensive effect of selenium and zinc capsules
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Fansidar drug induces cytotoxicity in some vital tissues in a rat model: combination defensive effect of selenium and zinc capsules

机译：淡粉药物在大鼠模型中的一些重要组织中诱导细胞毒性：硒和锌胶囊的组合防御效果

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Aim: Fansidar (FAN) is widely used as an antimalarial drug, but it may cause hepatoxicity, nephrotoxicity, and neurotoxicity. Hence, the study examines the cytoprotection of selenium (Se) and zinc (Zn) tablets against FAN induced toxicity. Method: Group I was given distilled water. Groups II, III, IV, and V received 50?mg/kg FAN by gavage. Group III was co-treated with a 50?mg/kg Se tablet. Group IV was co-treated with a 50?mg/kg Zn tablet. Group V was co-treated with a 50?mg/kg Se tablet? ?50?mg/kg Zn tablet. The exposure lasted for 7?days (sub-acute exposure). Result: FAN causes cytotoxicity through significant ( p??0.05) alteration of antioxidant molecules and hepatic enzymes. It also significantly ( p??0.05) induces renal, hepatocyte, and purkinje cell damage, but no visible lesion on testicular cells. The FAN induced cytotoxicity was significantly ( p??0.05) reversed on treatment with both single and combined antioxidant tablets. Conclusion: Our study supports the view that antioxidant micronutrient (Se and Zn) tablets may be a useful modulator in alleviating FAN induced oxidative stress and cytotoxicity in male rats. Plain language summary Combined selenium and zinc capsules: better therapy against cytotoxicity Fansidar was approved by United States’ Food and Drug Administration as an anti-malarial drug to treat acute and complicated malaria fever among patients in West Africa; however, its usage elicits toxicity to several organs of the body. It was elucidated that the combination of selenium and zinc capsules promotes organ wellness on co-treatment with Fansidar.
机译：目的：淡粉岛（风扇）广泛用作抗疟药，但它可能导致肝毒性，肾毒性和神经毒性。因此，该研究检测硒（SE）和锌（Zn）片对风机诱导毒性的细胞保护。方法：粒子I被蒸馏水。通过Gavage收到50个？Mg / kg风扇的II，III，IV组。 III组用50μg/ kg硒片进行共同处理。将IV组与50μg/ kg Zn平板电脑共同处理。 V组族与50？Mg / kg SE平板电脑共同处理？ ？50？mg / kg Zn平板电脑。曝光持续了7天（亚急性暴露）。结果：风扇通过显着（p≤0.05）抗氧化分子和肝酶的改变引起细胞毒性。它也显着（p≤≤0.05）诱导肾，肝细胞和紫癜细胞损伤，但在睾丸细胞上没有可见病变。风扇诱导的细胞毒性显着（p≤≤0.05）与单一和组合的抗氧化片进行逆转。结论：我们的研究支持抗氧化微量营养素（SE和Zn）片剂可以是减轻风扇诱导的氧化应激和雄性大鼠细胞毒性的有用调节剂。普通语言摘要联合硒和锌胶囊：通过美国食品和药物管理局作为一种抗疟疾药物来治疗西非患者的抗疟疾药物的细胞毒性瓦西多德的更好治疗;然而，它的用法引发了对身体的几个器官的毒性。阐明了硒和锌胶囊的组合促进了与绒毛达共同治疗的器官健康。

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