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首页> 外文期刊>Journal of Clinical Microbiology >A Look Inside: Oral Sampling for Detection of Non-oral Infectious Diseases
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A Look Inside: Oral Sampling for Detection of Non-oral Infectious Diseases

机译：内部看：口腔抽样检测非口腔传染病

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ABSTRACT Efforts to control transmissible infectious diseases rely on the ability to screen large populations, ideally in community settings. These efforts can be limited by the requirement for invasive or logistically difficult collection of patient samples, such as blood, urine, stool, sputum, and nasopharyngeal swabs. Oral sampling is an appealing, noninvasive alternative that could greatly facilitate high-throughput sampling in community settings. Oral sampling has been described for the detection of dozens of human pathogens, including pathogens whose primary sites of infection are outside of the oral cavity, such as the respiratory pathogens Mycobacterium tuberculosis and SARS-CoV-2. Oral sampling can demonstrate active infections as well as resolving or previous infections, the latter through the detection of antibodies. Its potential applications are diverse, including improved diagnosis in special populations (e.g., children), population surveillance, and infectious disease screening. In this minireview, we address the use of oral samples for the detection of diseases that primarily manifest outside the oral cavity. Focusing on well-supported examples, we describe applications for such methods and highlight their potential advantages and limitations in medicine, public health, and research.
机译：摘要控制传染病传染病的努力依赖于筛选大型人群的能力，理想地在社区环境中。这些努力可以受到侵袭性或逻辑上困难收集的患者样本的要求，例如血液，尿液，粪便，痰和鼻咽拭子。口头采样是一种吸引人，无创替代方案，可以极大地促进社区环境中的高吞吐量采样。已经描述了用于检测数十种人病原体的口腔取样，包括病原体，其主要感染部位在口腔外，例如呼吸道病原体分枝杆菌和SARS-COV-2。口腔抽样可以证明活性感染以及解决或先前的感染，后者通过检测抗体。其潜在的应用是多种多样的，包括改善特殊人群（例如，儿童），人口监测和传染病筛查的诊断。在这个MINIREVIEW中，我们解决了口腔样品的使用，以检测主要显现在口腔外的疾病。专注于支持良好的实例，我们描述了这些方法的应用，并突出了药物，公共卫生和研究中的潜在优势和局限性。

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