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首页> 外文期刊>BMC Neuroscience >Fibroblast growth factor 21 associating with serotonin and dopamine in the cerebrospinal fluid predicts impulsivity in healthy subjects
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Fibroblast growth factor 21 associating with serotonin and dopamine in the cerebrospinal fluid predicts impulsivity in healthy subjects

机译：成纤维细胞生长因子21与血清素和多巴胺相关联的脑脊液预测健康受试者的冲动

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Impulsivity is more commonly reported in subjects with mental disorders compared to healthy subjects, suggesting a potential application of impulsivity in predicting impulsivity-related mental disorders. However, no biomarker of impulsivity available so far. This study explored the association between cerebrospinal fluid (CSF) fibroblast growth factor 21 (FGF21), a key hormonal mediator of the stress response, and impulsivity in healthy subjects. A total of 126 healthy persons subjected to surgery of anterior cruciate ligament were recruited in the present study. The impulsiveness of the subjects was evaluated by the Chinese version of the Barratt Impulsiveness Scale (BIS)-11 before surgery. CSF and blood samples of the subjects were collected before spinal anesthesia for surgery. The levels of FGF21, serotonin and dopamine in CSF and the level of FGF21 in blood of the subjects were measured by ELISA using commercial kits. Negative correlations were found between BIS-11 total score and either FGF21, serotonin or dopamine in CSF. However, BIS-11 total score was not correlated with FGF21 in blood. In addition, FGF21 was positively correlated with serotonin and dopamine in CSF, respectively. Multivariable linear regression models indicated that the decrease of FGF21 level associating with the decrease of serotonin and dopamine level in CSF contributed to the higher impulsivity. Furthermore, receiver operating characteristic curve (ROC) analysis indicated an important role of CSF FGF21 predicting high impulsivity. FGF21, serotonin and dopamine in CSF associate with impulsivity in opposite directions. The decrease of CSF FGF21 is related to higher impulsivity, and indicate that CSF FGF21 may predict impulsivity in healthy subjects.
机译：与健康受试者相比，精神障碍的受试者中更常见地报告冲动，表明冲动预测与冲动相关的精神障碍的潜在应用。然而，到目前为止，没有禁止冲动的生物标志物。该研究探讨了脑脊液（CSF）成纤维细胞生长因子21（FGF21）之间的关联，应力反应的关键激素介质，以及健康受试者的冲动。在本研究中招募了共有126名患有前十字韧带手术的健康人。通过手术前的Barratt冲动量表（BIS）-11的中文版评估受试者的冲动。在脊柱麻醉前进行CSF和受试者的血液样本进行手术。使用商业试剂盒通过ELISA测量CSF中的FGF21，血清素和多巴胺和受试者血液中的FGF21水平。在CSF中的BIS-11总得分和FGF21，血清素或多巴胺之间发现了负相关性。然而，BIS-11总分与血液中的FGF21无关。此外，FGF21分别与​​CSF中的血清素和多巴胺呈正相关。多变量线性回归模型表明，CSF中血清素和多巴胺水平降低的FGF21水平降低导致脉冲较高。此外，接收器操作特征曲线（ROC）分析表明CSF FGF21预测高冲动的重要作用。 CSF中的FGF21，血清素和多巴胺与相反方向的冲动缔合。 CSF FGF21的降低与较高的冲动有关，并表明CSF FGF21可以预测健康受试者的冲动。

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