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首页> 外文期刊>BMC Neuroscience >Changes of cerebral cortical structure and cognitive dysfunction in “healthy hemisphere” after stroke: a study about cortical complexity and sulcus patterns in bilateral ischemic adult moyamoya disease
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Changes of cerebral cortical structure and cognitive dysfunction in “healthy hemisphere” after stroke: a study about cortical complexity and sulcus patterns in bilateral ischemic adult moyamoya disease

机译：中风后“健康半球”脑皮质结构和认知功能障碍的变化：双侧缺血成年莫达玛病中皮质复杂性和硫磺模式的研究

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Moyamoya disease (MMD) is an uncommon cerebrovascular disease which leads to progressive stenosis and occlusion of the bilateral internal carotid artery and main intracerebral arteries. Concerns are always on how the hemisphere with infarction affects cognitive function, while little attention is paid to the role that the non-infarcted hemisphere plays. Therefore, we aimed to detect cortical indexes, especially cortical complexity in the left or right hemisphere separately in patients with MMD after stroke. 28 patients with MMD (14 males, 14 females) and 14 healthy controls were included in this study. All participants underwent cognitive tests and magnetic resonance imaging (MRI) scan. The preprocessing of three-dimensional T1 weighted images were performed by standard surface-based morphometry. Surface-based morphometry statistical analysis was carried out with a threshold of False Discovery Rate (FDR) P??0.05 and fractal dimension (FD) was used to provide a quantitative description of cerebral cortical complexity. Widespread cognitive dysfunctions were found in MMD patient with stroke. Extensive FD reduction in the left hemisphere with right-sided infarction, mainly in the superior temporal, inferior frontal, and insula, while the post central gyrus, superior parietal, and inferior parietal gyrus also showed a wide range of significant differences (FDR corrected P??0.05). Meanwhile, FD changes in the right hemisphere with left-sided infarction are restricted to the precuneus and cingulate isthmus (FDR corrected P??0.05). Extensive cognitive impairment was reconfirmed in Moyamoya disease with stroke, while wild and asymmetrical decrease of cortical complexity is observed on both sides. These differences could be relative to unbalanced cognitive dysfunction, and may be the result of a long-term chronic ischemia and compensatory of the contralateral hemisphere to the infarction.
机译：Moyamoya病（MMD）是一种罕见的脑血管疾病，导致双侧内部颈动脉和主要脑内动脉的逐渐狭窄和闭塞。担心始终是如何与梗塞的半球如何影响认知功能，虽然对非梗塞半球的作用很少关注。因此，我们旨在检测皮质指数，特别是左半球在中风后MMD患者分别的皮质复杂性。本研究包括28例MMD（14名男性，14名女性）和14例健康对照。所有参与者都接受了认知测试和磁共振成像（MRI）扫描。通过标准表面的形态学进行三维T1加权图像的预处理。基于表面的形态学统计学分析用阈值进行假发现率（FDR）p≤≤0.05和分形维数（FD）来提供脑皮质复杂性的定量描述。患有中风的MMD患者中发现了普遍的认知功能障碍。广泛的FD减少左半球对右侧梗塞，主要是在颞率，劣势，额外和inslula，而中央回形后，优越的椎管和劣质间隙，均有很大的显着差异（FDR校正P ？＆ 0.05）。同时，左侧半球的FD变化左侧梗死的限制性被限制在前静脉上并递送肌动力（FDR校正P？＆ 0.05）。在Moyamoya疾病中重新认实了广泛的认知障碍，双方观察到皮质复杂性的野生和不对称降低。这些差异可能是相对于不平衡的认知功能障碍，并且可能是长期慢性缺血和对侧梗死的补偿性的结果。

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