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首页> 外文期刊>Colloids and Interfaces >Performance of Oleic Acid and Soybean Oil in the Preparation of Oil-in-Water Microemulsions for Encapsulating a Highly Hydrophobic Molecule
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Performance of Oleic Acid and Soybean Oil in the Preparation of Oil-in-Water Microemulsions for Encapsulating a Highly Hydrophobic Molecule

机译：油酸和大豆油在制备用于包封高疏水分子的水 - 水微乳液中的性能

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摘要

This work analyzes the dispersion of a highly hydrophobic molecule, (9Z)-N-(1,3-dihydroxyoctadecan-2-yl)octadec-9-enamide (ceramide-like molecule), with cosmetic and pharmaceutical interest, by exploiting oil-in-water microemulsions. Two different oils, oleic acid and soybean oil, were tested as an oil phase while mixtures of laureth-5-carboxylic acid (Akypo) and 2-propanol were used for the stabilization of the dispersions. This allowed us to obtain stable aqueous-based formulations with a relatively reduced content of oily phase (around 3% w/w), that may enhance the bioavailability of this molecule by its solubilization in nanometric oil droplets (with a size range of 30–80 nm), that allow the incorporation of a ceramide-like molecule of up to 3% w/w, to remain stable for more than a year. The nanometric size of the droplet containing the active ingredient and the stability of the formulations provide the basis for evaluating the efficiency of microemulsions in preparing formulations to enhance the distribution and availability of ceramide-like molecules, helping to reach targets in cosmetic and pharmaceutical formulations.
机译：该工作分析了高度疏水分子（9Z）-N-（1,3-二羟基癸辛烷-2-基）Octadec-9-酯（神经酰胺状分子）的分散，通过开采油 - 化妆品和药物兴趣水中微乳液。两种不同的油，油酸和大豆油被测试为油相，而Laureth-5-羧酸（Akypo）和2-丙醇的混合物用于稳定分散体。这使我们允许我们获得稳定的水性制剂，其具有相对降低的油相（约3％w / w）含量，这可以通过其在纳米油滴中的溶解（尺寸范围为30-）来提高该分子的生物利用度80nm），允许掺入高达3％w / w的神经酰胺状分子，保持稳定稳定超过一年。含有活性成分的液滴的纳米尺寸和制剂的稳定性为评估制备制剂中的微乳液的效率提供了基础，以提高神经酰胺样分子的分布和可用性，有助于在化妆品和药物制剂中获得靶标。

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