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Newborn telomere length and the early life origins of age-related disease

机译：新生地端粒长度和年龄相关疾病的早期生命

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In this EBioMedicine article, Dries Martens and colleagues report that newborn telomere length (TL) predicts TL in early childhood and young adulthood and that relative position within the TL distribution remains stable over time for the majority of study participants [1]. This work builds on previous studies that found evidence of so-called tracking and fixed ranking of TL in adults [2] and adolescents and their parents [3]. While the evidence for tracking and fixed ranking of TL appears to be somewhat weaker in childhood compared to adolescence and adulthood, taken together, the results of these studies draw attention to the importance of early life conditions in shaping trajectories of TL across the life course. This is particularly relevant in light of recent Mendelian randomization studies suggesting that TL plays a causal role in cardiovascular disease and cancer [4,5], the two leading causes of death in the US. Although there is a growing body of literature examining predictors of newborn and child TL (see, for example [6,7]), the overwhelming majority of telomere studies have focused on adults. If TL trajectories are indeed established in the first decade of life, as suggested by prior research on tracking and fixed ranking of TL [1 3], then researchers and funding agencies should prioritize research on the determinants of newborn and child TL. In order to facilitate the development of interventions to promote optimal TL in infants and children, this research should focus on the identification of modifiable environmental exposures, such as material deprivation, discrimination, and air pollution, which may impact TL in early life.
机译：在这个eBiomedicine文章中，Dries Martens及其同事报告说，新生儿端粒长度（TL）预测幼儿早期和年轻人的TL，而TL分布内的相对位置随着时间的推移对大多数研究参与者保持稳定[1]。这项工作建立在以前的研究中，发现了在成人[2]和青少年及其父母中所谓的跟踪和固定排名的证据表明[2]和父母[3]。虽然与青春期和成年期相比，童年的跟踪和固定排名的证据似乎有所疲软，但这些研究的结果引起了注意早期生命条件在整个生命课程中塑造TL轨迹的重要性。这尤其是孟德尔随机化研究特别相关的，表明TL在心血管疾病和癌症中发挥因果作用[4,5]，美国死亡的两种主要原因。虽然新生儿和儿童TL的文献检查备受符号的越来越多的体内（参见，例如[6,7]），绝大多数的重塑研究都集中在成年人身上。如果在生命的第一个十年内确实建立了TL轨迹，如先前研究TL的跟踪和固定排名所建议的[1 3]，那么研究人员和资助机构应优先考虑新生儿和儿童TL的决定因素的研究。为了促进干预措施来促进婴儿和儿童的最佳TL，这项研究应专注于可修改的环境暴露，如材料剥夺，歧视和空气污染，这可能会影响早期生命中的TL。

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