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The role of the microbiome in inflammation during tuberculosis

机译：微生物组在结核病炎症中的作用

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The human gut microbiota, comprised of a diverse microbial ecosystem, consists of hundreds of groups of species that are relatively stable in healthy individuals, but its composition can change rapidly as a result of illness, age, diet, antibiotic use, host genetics, and inflammation. Recent reports have shown that the microbiome may be implicated in tuberculosis (TB) infection [1,2]. TB is one of the most fatal infectious disease that is caused by the Mycobacterium tuberculosis complex and remains a major cause of global morbidity and mortality [3]. The microbiome and its associated metabolites are likely to play a role in susceptibility to TB infection and progression to and severity of disease. Changes in the structure of microbiome populations could impact immunity signaling. Gaining an in-depth understanding of the complex parameters of the relationship of the microbiome and TB infection could reveal key-elements that predict and modulate TB disease progression, severity, treatment outcomes and, possibly re-infection.
机译：由多种微生物生态系统组成的人体肠道微生物群，包括数百种相对稳定的健康个体的物种组成，但由于疾病，年龄，饮食，抗生素使用，宿主遗传学和炎。最近的报道表明，微生物组可以涉及结核病（TB）感染[1,2]。 TB是由结核分枝杆菌复杂的最具致命的传染病之一，仍然是全球发病率和死亡率的主要原因[3]。微生物组及其相关的代谢物可能在对TB感染和进展到疾病的易感性和进展中发挥作用。微生物组种群结构的变化可能影响免疫信号。对微生物组和Tb感染关系的复杂参数进行深入了解，可以揭示预测和调节TB疾病进展，严重程度，治疗结果以及可能再感染的关键元素。

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