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首页> 外文期刊>EBioMedicine >Potential clinical value of circular RNAs as peripheral biomarkers for the diagnosis and treatment of major depressive disorder
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Potential clinical value of circular RNAs as peripheral biomarkers for the diagnosis and treatment of major depressive disorder

机译：圆形RNA作为外周生物标志物的潜在临床价值，用于治疗重大抑郁症的诊断和治疗

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Background circular RNAs (circRNAs) are expressed abundantly in the brain and are implicated in the pathophysiology of neuropsychiatric disease. However, the potential clinical value of circRNAs in major depressive disorder (MDD) remains unclear. Methods RNA sequencing was conducted in whole-blood samples in a discovery set (7 highly homogeneous MDD patients and 7 matched healthy controls [HCs]). The differential expression of circRNAs was verified in an independent validation set. The interventional study was conducted to assess the potential effect of the antidepressive treatment on the circRNA expression. Findings in the validation set, compared with 52 HCs, significantly decreased circFKBP8 levels (Diff: -0.24; [95% CI -0.39 ~ -0.09]) and significantly elevated circMBNL1 levels (Diff: 0.37; [95% CI 0.09 ~ 0.64]) were observed in 53 MDD patients. The expression of circMBNL1 was negatively correlated with 24-item Hamilton Depression Scale (HAMD-24) scores in 53 MDD patients. A mediation model indicated that circMBNL1 affected HAMD-24 scores through a mediator, serum brain-derived neurotrophic factor. In 53 MDD patients, the amplitude of low-frequency fluctuations in the right orbital part middle frontal gyrus was positively correlated with circFKBP8 and circMBNL1 expression. Furthermore, the interventional study of 53 MDD patients demonstrated that antidepressive treatment partly increased circFKBP8 expression and the change in expression of circFKBP8 was predictive of further reduced HAMD-24 scores. Interpretation whole-blood circFKBP8 and circMBNL1 may be potential biomarkers for the diagnosis of MDD, respectively, and circFKBP8 may show great potential for the antidepressive treatment.
机译：背景环状RNA（circRNAs）在脑中大量表达和神经精神疾病的病理生理学有牵连。然而，在重度抑郁症（MDD）circRNAs的潜在的临床应用价值仍不清楚。方法RNA测序的全血样品中的在发现组进行（7名高度均匀的MDD患者和7个匹配的健康对照[碳氢化合物]）。 circRNAs的差异表达在一个独立的验证集进行了验证。介入研究以评估对circRNA表达抗抑郁治疗的潜在效应。在验证组的调查结果，与52层的HC相比，显著降低circFKBP8水平（DIFF：-0.24; [95％CI -0.39 -0.09〜]）和显著升高circMBNL1水平（DIFF：0.37; [95％CI 0.09〜0.64] ）在53名MDD患者中观察到。 circMBNL1的表达呈负在53名MDD患者24项汉密尔顿抑郁量表（HAMD-24）的分数相关。中介模型表明circMBNL1通过介体，血清脑源性神经营养因子的影响HAMD-24分数。在53例患者MDD，低频率波动的在右眼眶部额中回幅度随circFKBP8和circMBNL1表达呈正相关。此外，53名MDD患者的介入研究表明，抗抑郁治疗部分地增加circFKBP8表达和circFKBP8的表达的变化是预测的进一步减少HAMD-24分数。解读全血circFKBP8和circMBNL1可能是MDD，分别诊断潜在生物标志物，并circFKBP8可能会显示抗抑郁治疗的巨大潜力。

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