• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Prion >Prion protein polymorphisms in Michigan white-tailed deer ( Odocoileus virginianus )
【24h】

Prion protein polymorphisms in Michigan white-tailed deer ( Odocoileus virginianus )

机译：密歇根白尾鹿（Odocoileus virginianus）的朊病毒蛋白多态性

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Chronic Wasting Disease (CWD), a well-described transmissible spongiform encephalopathy of the Cervidae family, is associated with the aggregation of an abnormal isoform (PrP CWD ) of the naturally occurring host prion protein (PrP C ). Variations in the PrP gene ( PRNP ) have been associated with CWD rate of infection and disease progression. We analysed 568 free-ranging white-tailed deer ( Odocoileus virginianus ) from 9 CWD-positive Michigan counties for PRNP polymorphisms. Sampling included 185 CWD-positive, 332 CWD non-detected, and an additional 51 CWD non-detected paired to CWD-positives by sex, age, and harvest location. We found 12 polymorphic sites of which 5 were non-synonymous and resulted in a change in amino acid composition. Thirteen haplotypes were predicted, of which 11 have previously been described. Using logistic regression, consistent with other studies, we found haplotypes C (OR?=?0.488, 95% CI?=?0.321–0.730, P ?0.001) and F (OR?=?0.122, 95% CI?=?0.007–0.612, P ?0.05) and diplotype BC (OR?=?0.340, 95% CI?=?0.154–0.709, P ?0.01) were less likely to be found in deer infected with CWD. As has also been documented in other studies, the presence of a serine at amino acid 96 was less likely to be found in deer infected with CWD (P??0.001, OR?=?0.360 and 95% CI?=?0.227–0.556). Identification of PRNP polymorphisms associated with reduced vulnerability to CWD in Michigan deer and their spatial distribution can help managers design surveillance programmesand identify and prioritize areas for CWD management.
机译：慢性浪费疾病（CWD）是Cervidae家族的良好透氧海绵状脑病，与天然存在的宿主朊病毒蛋白（PRP C）的异常同种型（PRP CWD）的聚集有关。 PRP基因（PRNP）的变异与CWD感染率和疾病进展有关。我们分析了来自9个CWD阳性密歇根州的568个免费的白尾鹿（Odocoileus virginianus），从9个CWD积极的密歇根州县进行了PRNP多态性。采样包括185 CWD阳性，332CWD未检测到，并额外的51个CWD未检测到与CWD阳性的阳性以性别，年龄和收获位置配对。我们发现12个多晶型位点，其中5个是非同义的，导致氨基酸组合物的变化。预测了十三个单倍型，其中先前已经描述了11个。使用Logistic回归，与其他研究一致，我们发现单倍型C（或α= 0.488,95％CI？=α0.321-0.730，P＆ 0.001）和f（或？= 0.122,95％CI？= α007-0.612，p＆Δ05）和二丙型bc（或α= 0.340,95％ci？= 0.154-0.709，p＆Δ01）不太可能在感染CWD的鹿中发现。除其他研究中还记录，氨基酸96的丝氨酸的存在不太可能在感染CWD感染的鹿中（P 1 0.001，或α= 0.360和95％CI？0.227 -0.556）。鉴定密歇根鹿在CWD的降低脆弱性相关的PRNP多态性，它们的空间分布可以帮助管理人员设计监督程序和确定和优先考虑CWD管理领域。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号