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Development of Advanced Biodevices Using Quantum Beam Microfabrication Technology

机译：使用量子梁微型制备技术的高级生物开发

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Biodevices with engineered micro- and nanostructures are strongly needed for advancements in medical technology such as regenerative medicine, drug discovery, diagnostic reagents, and drug delivery to secure high quality of life. The authors produced functional biocompatible plastics and hydrogels with physical and chemical properties and surface microscopic shapes that can be freely controlled in three dimensions during the production process using the superior properties of quantum beams. Nanostructures on a biocompatible poly(L-lactic acid) surface were fabricated using a focused ion beam. Soft hydrogels based on polysaccharides were micro-fabricated using a focused proton beam. Gelatin hydrogels were fabricated using γ-rays and electron beam, and their microstructures and stiffnesses were controlled for biological applications. HeLa cells proliferated three-dimensionally on the radiation-crosslinked gelatin hydrogels and, furthermore, their shapes can be controlled by the micro-fabricated surface of the hydrogel. Long-lasting hydrophilic concave structures were fabricated on the surface of silicone by radiation-induced crosslinking and oxidation. The demonstrated advanced biodevices have potential applications in three-dimensional cell culture, gene expression control, stem cell differentiation induction/suppression, cell aggregation into arbitrary shapes, tissue culture, and individual diagnosis in the medical field.
机译：强烈需要具有工程化微型和纳米结构的生物化，以获得再生医学，药物发现，诊断试剂和药物递送以确保高质量的生命。作者用物理和化学性质和表面微观形状产生了功能性生物相容性塑料和水凝胶，其可以在生产过程中使用量子梁的优异特性在生产过程中自由控制。使用聚焦离子束制造生物相容性聚（L-乳酸）表面上的纳米结构。基于多糖的软水凝胶是使用聚焦质子束微型制造的。使用γ射线和电子束制造明胶水凝胶，并控制它们的微观结构和刚度用于生物应用。 Hela细胞在放射交联的明胶水凝胶上三维增殖，此外，它们的形状可以由水凝胶的微制造表面控制。通过辐射诱导的交联和氧化在硅氧烷表面上制造长持久的亲水性凹面结构。所证明的高级生物化学具有三维细胞培养，基因表达控制，干细胞分化诱导/抑制，细胞聚集成任意形状，组织培养以及医学领域的个体诊断中的潜在应用。

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