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首页> 外文期刊>Developmental cognitive neuroscience. >Associations among negative life events, changes in cortico-limbic connectivity, and psychopathology in the ABCD Study
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Associations among negative life events, changes in cortico-limbic connectivity, and psychopathology in the ABCD Study

机译：负面生活事件中的关联，在ABCD研究中的皮质 - 肢体连通性的变化以及精神病理学

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Adversity exposure is a risk factor for psychopathology, which most frequently onsets during adolescence, and prior research has demonstrated that alterations in cortico-limbic connectivity may account in part for this association. In a sample of youth from the Adolescent Brain Cognitive Development (ABCD) Study (N?=?4006), we tested a longitudinal structural equation model to examine the indirect effect of adversity exposure (negative life events) on later psychopathology via changes in cortico-limbic resting-state functional connectivity (rsFC). We also examined the potential protective effects of parental acceptance. Generally, cortico-limbic connectivity became more strongly negative between baseline and year 2 follow-up, suggesting that stronger negative correlations within these cortico-limbic networks may reflect a more mature phenotype. Exposure to a greater number of negative life events was associated with stronger negative cortico-limbic rsFC which, in turn, was associated with lower internalizing (but not externalizing) symptoms. The indirect effect of negative life events on internalizing symptoms via cortico-limbic rsFC was significant. Parental acceptance did not moderate the association between negative life events and rsFC. Our findings highlight how stressful childhood experiences may accelerate neurobiological maturation in specific cortico-limbic connections, potentially reflecting an adaptive process that protects against internalizing problems in the context of adversity.
机译：逆境暴露是精神病理学的危险因素，青春期期间最常见的持续性，并且先前的研究表明，皮质 - 肢体连接中的改变可能会占这个协会的一部分。在来自青少年脑认知发展（ABCD）研究的青年样本中（n？= 4006），我们测试了纵向结构方程模型，以检查逆向暴露（负寿命事件）的间接效应通过Cortico的变化来检查后来的精神病理学-LIMBIC休息状态功能连接（RSFC）。我们还研究了父母验收的潜在保护作用。通常，基线和第2年的后续跟踪之间的皮质 - 肢体连接变得更加强烈，这表明这些皮质肢网络中的负相关性更强可能反映更成熟的表型。暴露于更多的负寿命事件与较强的阴性皮质 - 肢体RSFC相关，这反过来又与较低的内化（但不外化）症状相关。负面生活事件对通过皮质肢体RSFC进行内化症状的间接影响是显着的。父母的验收没有审核负面生活事件和RSFC之间的关联。我们的调查结果强调了童年的体现程度如何在特定的皮质 - 肢体连接中加速神经生成的成熟，可能反映了保护逆境背景下的内化问题的自适应过程。

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