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首页> 外文期刊>Developmental cognitive neuroscience. >A transdiagnostic data-driven study of children’s behaviour and the functional connectome
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A transdiagnostic data-driven study of children’s behaviour and the functional connectome

机译：儿童行为和功能连接的跨透明数据驱动研究

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Behavioural difficulties are seen as hallmarks of many neurodevelopmental conditions. Differences in functional brain organisation have been observed in these conditions, but little is known about how they are related to a child’s profile of behavioural difficulties. We investigated whether behavioural difficulties are associated with how the brain is functionally organised in an intentionally heterogeneous and transdiagnostic sample of 957 children aged 5–15. We used consensus community detection to derive data-driven profiles of behavioural difficulties and constructed functional connectomes from a subset of 238 children with resting-state functional Magnetic Resonance Imaging (fMRI) data. We identified three distinct profiles of behaviour that were characterised by principal difficulties with hot executive function, cool executive function, and learning. Global organisation of the functional connectome did not differ between the groups, but multivariate patterns of connectivity at the level of Intrinsic Connectivity Networks (ICNs), nodes, and hubs significantly predicted group membership in held-out data. Fronto-parietal connector hubs were under-connected in all groups relative to a comparison sample and children with hot vs cool executive function difficulties were distinguished by connectivity in ICNs associated with cognitive control, emotion processing, and social cognition. This demonstrates both general and specific neurodevelopmental risk factors in the functional connectome.
机译：行为困难被视为许多神经发育状况的标志。在这些条件下观察到功能性脑组织的差异，但对于他们如何与孩子的行为困难的概况有关。我们调查了行为困难是否与大脑如何在5-15岁的957例儿童的有意的异质和转诊样品中有关。我们使用共识社区检测来导出行为困难的数据驱动的概况，并从238个儿童的子集构成功能互连，具有休息状态功能磁共振成像（FMRI）数据。我们确定了三种不同的行为曲线，其特征是具有热门执行功能，酷行政职能和学习的主要困难。全局组织的功能连接在组之间没有区别，但在内部连接网络（ICNS），节点和集线器的级别的多变量的连接模式显着预测了所持数据中的组成员资格。各个顶板连接器集线器在相对于比较样本中底层，相对于比较样本，并且具有热的VS儿童冷静执行功能难以与认知控制，情感处理和社会认知相关的ICN中的连接。这证明了功能性连接中的一般和特异性神经发育风险因素。

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