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首页> 外文期刊>JMIR public health and surveillance. >Current smoking and SARS-CoV-2 infection: findings from the Italian cross-sectional EPICOVID19 internet-based survey.
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Current smoking and SARS-CoV-2 infection: findings from the Italian cross-sectional EPICOVID19 internet-based survey.

机译：目前的吸烟和SARS-COV-2感染：意大利横断面epicovid19基于互联网的调查结果。

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Background Several studies have reported a low prevalence of current smoking among hospitalized COVID-19 cases; however, no definitive conclusions can be drawn. Objective We investigated the association of tobacco smoke exposure with nasopharyngeal swab (NPS) test results for SARS-CoV-2 infection and disease severity accounting for possible confounders. Methods The nationwide, self-administered, cross-sectional web-based Italian National Epidemiological Survey on COVID-19 (EPICOVID19) was administered to an Italian population of 198,822 adult volunteers who filled in an online questionnaire between April 13 and June 2, 2020. For this study, we analyzed 6857 individuals with known NPS test results. The associations of smoking status and the dose-response relationship with a positive NPS test result and infection severity were calculated as odds ratios (ORs) with 95% CIs by means of logistic and multinomial regression models adjusting for sociodemographic, clinical, and behavioral characteristics. Results Out of the 6857 individuals (mean age 47.9 years, SD 14.1; 4516/6857, 65.9% female), 63.2% (4334/6857) had never smoked, 21.3% (1463/6857) were former smokers, and 15.5% (1060/6857) were current smokers. Compared to nonsmokers, current smokers were younger, were more educated, were less affected by chronic diseases, reported COVID-19–like symptoms less frequently, were less frequently hospitalized, and less frequently tested positive for COVID-19. In multivariate analysis, current smokers had almost half the odds of a positive NPS test result (OR 0.54, 95% CI 0.45-0.65) compared to nonsmokers. We also found a dose-dependent relationship with tobacco smoke: mild smokers (adjusted OR [aOR] 0.76, 95% CI 0.55-1.05), moderate smokers (aOR 0.56, 95% CI 0.42-0.73), and heavy smokers (aOR 0.38, 95% CI 0.27-0.53). This inverse association also persisted when considering the severity of the infection. Current smokers had a statistically significantly lower probability of having asymptomatic (aOR 0.50, 95% CI 0.27-0.92), mild (aOR 0.65, 95% CI 0.53-0.81), and severe infections (aOR 0.27, 95% CI 0.17-0.42) compared to those who never smoked. Conclusions Current smoking was negatively associated with SARS-CoV-2 infection with a dose-dependent relationship. Ad hoc experimental studies are needed to elucidate the mechanisms underlying this association.
机译：背景技术几项研究报告，在住院的Covid-19案件中，目前的吸烟率低;但是，无法得出明确的结论。目的我们调查了烟草烟雾暴露与鼻咽拭子（NPS）测试结果的关联，对SARS-COV-2感染和疾病严重性核算可能的混淆。方法对全国范围内，自我管理的横截面Web的意大利国家流行病学调查对Covid-19（Epicovid19）的意大利人口施入198,822名成年志愿者的意大利人口，他们于2020年4月2日至6月2日之间填写在线问卷。对于这项研究，我们分析了6857个具有已知NPS测试结果的个体。吸烟状态和剂量 - 反应关系与阳性NPS测试结果和感染严重程度的关联是通过调整社会阶段，临床和行为特征的逻辑和多元回归模型为95％CIS的优点比率（ORS）。结果6857人（平均年龄47.9岁，SD 14.1; 4516/6857，65.9％的女性），63.2％（4334/6857）从未吸烟，21.3％（1463/6857）是前吸烟者，15.5％（ 1060/6857）是目前的吸烟者。与非吸烟者相比，目前的吸烟者较年轻，受过较高的教育，受慢性疾病的影响较小，报道的Covid-19样症状较少，不太频繁地住院，并且对Covid-19的频率不太频繁测试。在多变量分析中，与非吸烟者相比，目前的吸烟者几乎具有阳性NPS测试结果（或0.54,95％CI 0.45-0.65）的几乎没有几率。我们还发现与烟草烟雾的剂量依赖关系：轻度吸烟者（调节或[AOR] 0.76,95％CI 0.55-1.05），中度吸烟者（AOR 0.56,95％CI 0.42-0.73）和重型吸烟者（AOR 0.38 ，95％CI 0.27-0.53）。在考虑感染的严重程度时，这种逆关联也持续存在。目前的吸烟者具有统计学上显着降低的无症状的概率（AOR 0.50,95％CI 0.27-0.92），温和（AOR 0.65,95％CI 0.53-0.81）和严重的感染（AOR 0.27,95％CI 0.17-0.42）与那些从未吸烟的人相比。结论目前的吸烟与具有剂量依赖关系的SARS-COV-2感染对抗。需要临时实验研究来阐明本协会的基础机制。

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