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首页> 外文期刊>JMIR public health and surveillance. >Increases in Naloxone Administrations by Emergency Medical Services Providers During the COVID-19 Pandemic: Retrospective Time Series Study
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Increases in Naloxone Administrations by Emergency Medical Services Providers During the COVID-19 Pandemic: Retrospective Time Series Study

机译：在Covid-19大流行期间，紧急医疗服务提供者增加纳洛酮管理局：回顾性时间序列研究

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Background The opioid crisis in the United States may be exacerbated by the COVID-19 pandemic. Increases in opioid use, emergency medical services (EMS) runs for opioid-related overdoses, and opioid overdose deaths have been reported. No study has examined changes in multiple naloxone administrations, an indicator of overdose severity, during the COVID-19 pandemic. Objective This study examines changes in the occurrence of naloxone administrations and multiple naloxone administrations during EMS runs for opioid-related overdoses during the COVID-19 pandemic in Guilford County, North Carolina (NC). Methods Using a period-over-period approach, we compared the occurrence of opioid-related EMS runs, naloxone administrations, and multiple naloxone administrations during the 29-week period before (September 1, 2019, to March 9, 2020) and after NC’s COVID-19 state of emergency declaration (ie, the COVID-19 period of March 10 to September 30, 2020). Furthermore, historical data were used to generate a quasi-control distribution of period-over-period changes to compare the occurrence of each outcome during the COVID-19 period to each 29-week period back to January 1, 2014. Results All outcomes increased during the COVID-19 period. Compared to the previous 29 weeks, the COVID-19 period experienced increases in the weekly mean number of opioid-related EMS runs (25.6, SD 5.6 vs 18.6, SD 6.6; P.001), naloxone administrations (22.3, SD 6.2 vs 14.1, SD 6.0; P.001), and multiple naloxone administrations (5.0, SD 1.9 vs 2.7, SD 1.9; P.001), corresponding to proportional increases of 37.4%, 57.8%, and 84.8%, respectively. Additionally, the increases during the COVID-19 period were greater than 91% of all historical 29-week periods analyzed. Conclusions The occurrence of EMS runs for opioid-related overdoses, naloxone administrations, and multiple naloxone administrations during EMS runs increased during the COVID-19 pandemic in Guilford County, NC. For a host of reasons that need to be explored, the COVID-19 pandemic appears to have exacerbated the opioid crisis.
机译：背景技术美国阿片类药物危机可能被Covid-19大流行加剧。阿片类药物的增加，应急医疗服务（EMS）用于阿片类药物相关的产量，并报告了阿片类药物过量死亡。在Covid-19大流行期间，尚未研究过多种纳洛酮管理局的变化，过量严重程度的指标。目的本研究检查了在北卡罗来纳州桂福县的Covid-19大流行期间EMS与阿片类药物相关的过量的EMS中纳洛酮施用和多种纳洛酮组织发生的变化。使用期间过期方法的方法，比较了在29周期间（2019年9月1日至3月9日）和NC之后的29周期间在29周期间发生了与诺罗西酮醛运行，纳洛酮组和多个纳洛酮管理的发生。 Covid-19紧急宣言状态（即Covid-19 3月10日至9月30日）。此外，历史数据用于生成时期过期变化的准控制分布，以比较Covid-19期间每个结果的发生时间，返回2014年1月1日。结果所有结果都增加了在Covid-19期间。与过去29周相比，Covid-19期间经历了每周平均相关的EMS数量的增加（25.6，SD 5.6，SD 6.6，SD 6.6; P＆ .001），Naloxone主管部门（22.3，SD 6.2 VS 14.1，SD 6.0; p＆ .001）和多种纳洛酮施用（5.0，SD 1.9 Vs 2.7，SD 1.9; P＆ .001），分别对应于比例增加37.4％，57.8％和84.8％。此外，Covid-19期间的增加占分析所有历史29周的91％。结论EMS相关产量的EMS运行的发生效果，在EMS县的Covid-19大流行期间，在EMS中的纳洛酮组和多种纳洛酮施用在北卡州省的Covid-19大流行期间增加。对于需要探索的一系列原因，Covid-19大流行似乎加剧了阿片类药物危机。

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