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首页> 外文期刊>Journal of International Medical Research >Effects of incretin-based therapies on β-cell function in type 1 diabetes mellitus: a systematic review and meta-analysis
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Effects of incretin-based therapies on β-cell function in type 1 diabetes mellitus: a systematic review and meta-analysis

机译：基于Incetin的疗法对1型糖尿病β细胞功能的影响：系统评价和荟萃分析

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Aim To assess the effects of incretin-based therapies on β-cell function in patients with type 1 diabetes mellitus (T1DM). Methods We searched the PubMed, Cochrane Library, Embase, and Web of Knowledge databases for eligible randomized clinical trials published up to July 2021. The inclusion criteria were patients with T1DM or latent autoimmune diabetes in adults, patients treated with dipeptidyl peptidase-4 inhibitors or glucagon like peptide-1 receptor agonists, and outcomes included one of the following: fasting plasma glucose, fasting C-peptide, postprandial C-peptide, C-peptide area under the curve (AUC), homeostasis model assessment for β cell function, and insulin resistance. The effects were analyzed using a random effect model with STATA 11.0. Results Eight trials including 427 participants were included in the final analysis. A pooled analysis found no significant difference in fasting plasma glucose, fasting C-peptide, postprandial C-peptide, or C-peptide AUC between patients treated with incretin-based therapies and placebo. The two trials that reported changes in 2-hour postprandial C-peptide and two of the four trials that reported changes in C-peptide AUC reported increases after incretin-based therapies. Conclusion This meta-analysis showed that incretin-based therapies did not preserve β-cell function in patients with T1DM.
机译：目的评估基于Incetin的疗法对1型糖尿病（T1DM）患者β细胞功能的影响。方法搜索了符合条件的随机临床试验的PubMed，Cochrane图书馆，Embase，Embase，Embase和网络网络网络，含有条件的随机临床试验，纳入患者是成人患者的T1DM或潜在的自身免疫糖尿病患者，患者用二肽基肽酶-4抑制剂或患者肽如肽-1受体激动剂等胰高血糖素包括以下内容：禁食血浆葡萄糖，禁食C-肽，后丙肽，曲线（AUC）下的C肽区域，β细胞功能的稳态模型评估，以及胰岛素抵抗。使用具有STATA 11.0的随机效应模型进行分析这些效果。结果八项试验，包括427名参与者的终点分析。汇总分析发现，在基于Incetin的疗法和安慰剂治疗的患者之间存在禁食血浆葡萄糖，空腹C-肽，餐后C-肽或C肽AUC的显着差异。报告的两项试验报告了2小时餐后C-肽的变化，并报告了基于Incetin的疗法后报告的C-肽AUC的变化的两项试验中的两项试验。结论该荟萃分析表明，基于Incetin的疗法在T1DM患者中没有保留β细胞功能。

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