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首页> 外文期刊>Journal of International Medical Research >Potential predictive value of plasma heat shock protein 90α in lung cancer
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Potential predictive value of plasma heat shock protein 90α in lung cancer

机译：肺癌中血浆热休克蛋白90α的潜在预测值

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Objective Heat shock protein 90α (HSP90α) is associated with cancer development, progression, and metastasis. This study assessed the relationships of plasma HSP90α levels with treatment efficacy and prognosis in lung cancer. Methods In this retrospective cross-sectional study, 231 patients with lung cancer were enrolled from 1 September 2016 to 31 December 2019. HSP90α levels were measured before and after treatment, and their relationships with outcomes were assessed. Results Patients with elevated HSP90α levels before treatment had a better overall response rate (ORR, 44.1% vs. 30.6%), whereas the disease control rate did not differ between patients with elevated and normal HSP90α levels (81% vs. 78.5%). Median progression-free survival (PFS) was 6.9 months in patients with elevated baseline HSP90α levels, versus 9 months in patients with normal HSP90α levels, whereas the median overall survival (OS) times in these groups were 12 and 14.1 months, respectively. Concerning HSP90α levels after treatment, ORR (20% vs. 47.1%) and DCR (67.3% vs. 90.9%) were lower in patients with increased HSP90α levels, and PFS and OS were also significantly different between the groups. Conclusions HSP90α levels before and after treatment were associated with treatment response and patient prognosis in lung cancer.
机译：客观热休克蛋白90α（HSP90α）与癌症发育，进展和转移相关。该研究评估了血浆HSP90α水平与肺癌治疗疗效和预后的关系。方法在本回顾性横截面研究中，231例肺癌患者于2016年9月1日至2019年12月31日招募。治疗前后测量HSP90α水平，评估其与结果的关系。结果治疗前的HSP90α水平升高的患者具有更好的整体反应率（ORR，44.1％vs.30.6％），而患者在HSP90α水平升高（81％vs.78.5％）之间没有差异。基线HSP90α水平升高的患者中，中位进展生存期（PFS）为6.9个月，患者与正常HSP90α水平的患者，而这些组中的中位数存活率（OS）时间分别为12和14.1个月。对于HSP90α水平较高的患者，治疗后的HSP90α水平，ORR（20％vs.47.1％）和DCR（67.3％与90.9％）降低，PFS和OS在组之间也显着差异。结论治疗前后的HSP90α水平与肺癌治疗响应和患者预后有关。

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