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首页> 外文期刊>Journal of International Medical Research >Prognostic significance of clinical characteristics and 18Fluorodeoxyglucose-positron emission tomography/computed tomography quantitative parameters in patients with primary mediastinal B-cell lymphoma
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Prognostic significance of clinical characteristics and 18Fluorodeoxyglucose-positron emission tomography/computed tomography quantitative parameters in patients with primary mediastinal B-cell lymphoma

机译：临床特征及 18 氟脱氧葡萄糖 - 正电子发射断层扫描/计算机断层扫描定量参数的预后意义初级纵隔B细胞淋巴瘤

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Objective Primary mediastinal B-cell lymphoma (PMBCL) lacks standard treatment regimens. This study aimed to identify the disease’s clinical features and prognostic factors. Methods This retrospective study included 56 patients with PMBCL. Patient demographic details and clinicopathological characteristics were summarized, and their effects on progression-free survival (PFS) and overall survival (OS) were analyzed. Results The median patient age was 29 years (range, 14–56). Twenty-two patients received DA-EPOCH-R (dose-adjusted etoposide, vincristine, and doxorubicin for 96 hours with bolus doses of cyclophosphamide and oral prednisone, as well as rituximab), and 34 patients received R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone). Clinical/laboratory parameters, overall response rates, and 5-year PFS and OS rates did not differ between the treatment groups. Kaplan–Meier analysis indicated that late-stage disease and a higher International Prognostic Index (IPI) were associated with shorter PFS and OS. Furthermore, patients with B symptoms and first-line treatment non-responders exhibited worse OS. ~(18)Fluorodeoxyglucose-positron emission tomography/computed tomography quantitative parameters, such as higher metabolic tumor volume (MTV) and total lesion glycolysis (TLG), were corrected with shorter PFS. Conclusions This study revealed that stage IV disease, higher IPI, and B symptoms were poor prognostic factors in patients with PMBCL. Significantly, higher MTV and TLG portended worse PFS.
机译：目标原发性纵隔B细胞淋巴瘤（PMBCL）缺乏标准治疗方案。本研究旨在鉴定疾病的临床特征和预后因素。方法本回顾性研究包括56例PMBCL患者。总结了患者人口统计细节和临床病理特征，分析了它们对无进展生存（PFS）和总存活（OS）的影响。结果中位数患者年龄为29岁（范围，14-56）。 22名患者接受DA-EPOCH-R（剂量调节的依托普苷，长春螯合物，含有推注的环磷酰胺和口服泼尼松，以及Rituximab），以及34名患者R-Chec（Rituximab，环磷酰胺，多柔比星，血管素，泼尼松）。临床/实验室参数，整体反应率和5年的PFS和OS率在治疗组之间没有区别。 Kaplan-Meier分析表明，晚期疾病和更高的国际预后指数（IPI）与更短的PFS和OS相关。此外，B症状和一线治疗的患者表现出更糟的OS。 〜（18）氟脱氧葡萄糖 - 正电子发射断层扫描/计算断层扫描定量参数，例如较高的代谢肿瘤体积（MTV）和总损伤糖酵解（TLG），用较短的PFS校正。结论本研究表明，阶段IV疾病，较高的IPI和B症状对PMBCL患者的预后因素差。值得注意的是，更高的MTV和TLG预期了更差的PFS。

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