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首页> 外文期刊>Journal of International Medical Research >Correlation between vitamin D levels and bone metabolism in children with cow’s milk allergy
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Correlation between vitamin D levels and bone metabolism in children with cow’s milk allergy

机译：牛奶过敏儿童维生素D水平与骨代谢的相关性

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Objective Research is limited regarding biochemical markers of bone metabolism among children with cow’s milk protein allergy (CMPA). We aimed to determine differences in vitamin D and bone metabolism markers between infants with CMPA and healthy infants and explore relationships between these in a cross-sectional study. Methods In total, we included 41 children diagnosed with CMPA and under systematic medical and nutritional care at our center, and 50 healthy children as a control group. We reviewed demographic and clinical characteristics and measured serum biomarkers. Results We found that serum 25-hydroxyvitamin D (25(OH)D) levels among infants in the CMPA group were significantly lower than those in the control group, and levels of bone-specific alkaline phosphatase (BALP), serum phosphorus, and serum calcitonin were reduced. Pearson correlation analysis showed that serum 25(OH)D concentrations in the CMPA group were negatively correlated with parathyroid hormone but not significantly correlated with calcitonin and BALP. Logistic regression showed that CMPA was a risk factor for vitamin D deficiency. Conclusions Our study indicated that CMPA was associated with disturbances in bone metabolism. Levels of vitamin D in children with CMPA were lower than those in healthy children. CMPA was a risk factor for vitamin D deficiency.
机译：关于牛奶蛋白过敏（CMPA）的儿童骨代谢生物化学标志物的客观研究有限。我们的旨在确定婴儿与CMPA和健康婴儿之间的维生素D和骨代谢标志物的差异，并在横断面研究中探索这些关系。方法总共包括41名儿童，诊断患有CMPA，并在我们的中心进行系统的医疗和营养护理，以及50名健康儿童作为对照组。我们审查了人口统计学和临床​​特征和测量的血清生物标志物。结果我们发现CMPA组婴儿的血清25-羟基乙素D（25（OH）D）水平明显低于对照组中的水平，以及骨特异性碱性磷酸酶（BALP），血清磷和血清水平降低降钙素。 Pearson相关性分析表明，CMPA组中的血清25（OH）D浓度与甲状旁腺激素负相关，但与降钙素和Balp没有显着相关。 Logistic回归显示CMPA是维生素D缺乏的危险因素。结论我们的研究表明，CMPA与骨代谢的干扰有关。 CMPA儿童中的维生素D水平低于健康儿童的水平。 CMPA是维生素D缺乏的危险因素。

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