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首页> 外文期刊>Journal of International Medical Research >Effect of glutathione S-transferase gene polymorphisms on semen quality in patients with idiopathic male infertility
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Effect of glutathione S-transferase gene polymorphisms on semen quality in patients with idiopathic male infertility

机译：谷胱甘肽S转移酶基因多态性对特发性男性不孕症患者精液质量的影响

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Objective To investigate the relationship between glutathione S-transferase enzyme ( GSTM1 , T1 , and P1 ) genetic variants and semen quality in men with idiopathic infertility. Methods Sperm characteristics were measured using computer-assisted sperm analysis. The malondialdehyde (MDA), nitric oxide (NO), and total antioxidant capacity (TAC) activities were detected by spectroscopic analysis, and 8-hydroxy-2′-deoxyguanosine (8-OHdG) was detected by enzyme-linked immunosorbent assay. Results This study included 246 idiopathic infertile men and 117 controls. The GSTM1 (?), T1 (?), and M1/T1 (?/?) genotype frequencies significantly differed between the groups. The GSTM1 (?) and T1 (?) genotypes in idiopathic infertile men negatively correlated with sperm concentration, motility, mitochondrial membrane potential, and other parameters. However, these genotypes positively correlated with the amplitude of the lateral head displacement and NO and 8-OHdG levels. The GSTT1 (?) genotype positively correlated with mean angular displacement and MDA activity. GSTM1 (?) and T1 (?) had a synergistic effect on semen quality. Sperm motility, normal morphology, straightness, and TAC were lower and amplitude of lateral head displacement and MDA were higher in the GSTP1(A/G?+?G/G) group than in the GSTP1(A/A) group among men with idiopathic infertility. Conclusions GSTM1 , T1 , and P1 genetic variants may be risk factors for infertility by affecting the semen quality men with idiopathic oligoasthenospermia.
机译：目的探讨具有特发性不孕症的男性谷胱甘肽S-转移酶（GSTM1，T1和P1）遗传变异和精液质量的关系。方法使用计算机辅助精液分析测量精子特性。通过光谱分析检测丙二醛（MDA），一氧化氮（NO）和总抗氧化能力（TAC）活性，并通过酶联免疫吸附测定检测8-羟基-2'-脱氧核苷酸（8-OHDG）。结果本研究包括246名特发性不孕症男性和117个对照。 GSTM1（α），T1（？）和M1 / T1（β/α）基因型频率在组之间显着不同。特发性不孕症的GSTM1（？）和T1（α）基因型与精子浓度，运动，线粒体膜电位和其他参数负相关。然而，这些基因型与横向头位移的幅度和NO和8-OHDG水平正相关。 GSTT1（α）基因型与平均角位移和MDA活性呈正相关。 GSTM1（？）和T1（？）对精液质量具有协同效应。精子运动，正常形态，直线度和TAC较低，横向头部位移的幅度和MDA在GSTP1（A /g≤1×g / g）组中高于男性的GSTP1（A / A）组特发性不孕症。结论GSTM1，T1和P1遗传变异可能是通过影响具有特发性寡核苷酸植物的精液优质的男性来危险因素。

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