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首页> 外文期刊>Journal of International Medical Research >Lymphocyte and macrophage infiltration in omental metastases indicates poor prognosis in advance stage epithelial ovarian cancer
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Lymphocyte and macrophage infiltration in omental metastases indicates poor prognosis in advance stage epithelial ovarian cancer

机译：在题转移中的淋巴细胞和巨噬细胞浸润表明预后预后似乎是上皮卵巢癌

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Objective To investigate the prognostic value of immune cells within omental metastases originating from advanced epithelial ovarian cancer (EOC). Methods We performed immunohistochemical analysis to determine the levels of CD4+/CD8+ tumor-infiltrating lymphocytes (TILs) and CD68+ tumor-associated microphages (TAMs) in omental specimens from 100 patients with advanced EOC. Significant prognostic factors, including immune cells and clinical parameters, were assessed by Kaplan–Meier survival analysis and Cox models. Results Cox regression analysis showed that elevated levels of CD68+ TAMs and intra-islet CD4+ TILs in omental metastases were the main risk factors associated with worse survival outcomes for advanced EOC. Moreover, the survival analysis of relationships between omental immune cells and favorable clinical predictors revealed additional prognostic stratification information. Conclusion Omental immune cells (TAMs and TILs) provide alternative prognostic factors in advanced EOC. In contrast to markers of the EOC tumor microenvironment at the primary site, elevated CD68+ TAMs and intra-islet CD4+ TILs in omental metastases serve as negative prognostic markers in advanced EOC and imply an unfavorable outcome.
机译：目的探讨源自晚期上皮性卵巢癌（EOC）题术中免疫细胞的预后价值。方法采用免疫组织化学分析，从100例高级EOC的患者确定免疫组织化学分析以确定从100例患者中确定CD4 + / CD8 +肿瘤浸润淋巴细胞（TIL）和CD68 +肿瘤相关的微观（TAMS）。通过Kaplan-Meier存活分析和COX模型评估了显着的预后因素，包括免疫细胞和临床参数。结果Cox回归分析表明，在Omental转移中升高的CD68 + Tams和胰岛内CD4 + TILs的水平是与高级EOC的更严重的生存结果相关的主要风险因素。此外，肉体免疫细胞和有利的临床预测因子之间关系的存活分析揭示了另外的预后分层信息。结论Omental免疫细胞（TAMS和TILs）为先进的EOC提供替代预后因素。与原发性部位的EOC肿瘤微环境的标记相反，题转移中的CD68 + TAM和胰岛内CD4 + TILS的升高为晚期EOC的阴性预后标志物，并意味着不利的结果。

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