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A study on the curative effect of nobiletin on paraquat induced toxicity in rat

机译：Nobiletin对大鼠拟肽诱导毒性的疗效研究

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This research aimed to evaluate the curative impact of nobiletin (NOB) on paraquat (PQ) induced mitochondrial impairment in rats' hepatic tissues. Twenty-four male rats were divided into control, PQ, PQ?+?NOB, and NOB treated groups. The alanine aminotransferase levels, aspartate aminotransferase, and alkaline phosphatase were increased in the experimental animals after exposure with PQ. A significant decrease in the level of catalase, glutathione peroxidase, superoxide dismutase, glutathione, thiobarbituric acid reactive substances, and reactive oxygen species were recorded in rats exposed to PQ. The mitochondrial TCA cycle enzyme activities, including isocitrate-dehydrogenase, succinate-dehydrogenase, alpha-ketoglutarate dehydrogenase, and malate-dehydrogenase, were reduced in PQ exposed rats. The activities of mitochondrial enzymes including NADH dehydrogenase, coenzyme Q-cytochrome reductase, succinic-coenzyme Q and cytochrome c-oxidase were significantly decreased after the PQ-exposure. PQ administration also reduced the mitochondrial membrane potential. However, the administration of mitochondria with NOB can decrease the toxic effect of the PQ in isolated mitochondria. NOB treatment potentially reduced the damaging effects of the PQ in the mitochondria isolated from hepatic tissues. Thus, the current study revealed that the NOB could attenuate PQ-induced mitochondrial damage in rats' hepatic tissues.
机译：该研究旨在评估Nobiletin（Nob）对大鼠肝组织诱导的线粒体损伤的疗效影响。将二十四只雄性大鼠分为对照，PQ，PQ？+？NOB和NOB治疗组。在用PQ暴露后，在实验动物中增加了丙氨酸氨基转移酶水平，天冬氨酸氨基转移酶和碱性磷酸酶。在暴露于PQ的大鼠中，记录过氧化氢酶，谷胱甘肽过氧化物酶，超氧化物歧化酶，谷胱甘肽，硫酰比脲酸反应性物质和反应性氧物质的显着降低。在PQ暴露大鼠中，降低了在PQ暴露大鼠中减少了线粒体TCA循环酶活性，包括异柠檬酸脱氢酶，琥珀酸脱氢酶，琥珀酸脱氢酶，α-酮戊二酸脱氢酶和亚羟乙酸脱氢酶。在PQ暴露后显着降低了在包括NADH脱氢酶，辅酶Q-细胞色素还原酶，琥珀酶Q-细胞Q和细胞色素C-氧化酶的情况下的线粒体酶的活性。 PQ管理还降低了线粒体膜电位。然而，具有NOB的线粒体的给药可以降低分离的线粒体中PQ的毒性作用。 NOB治疗可能降低了PQ在肝脏组织中分离的线粒体中的损伤作用。因此，目前的研究表明，NOB可以衰减大鼠肝组织中PQ诱导的线粒体损伤。

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