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首页> 外文期刊>Journal of King Saud University >Thymoquinone nanoparticles protect against cisplatin-induced nephrotoxicity in Ehrlich carcinoma model without compromising cisplatin anti-cancer efficacy
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Thymoquinone nanoparticles protect against cisplatin-induced nephrotoxicity in Ehrlich carcinoma model without compromising cisplatin anti-cancer efficacy

机译：胸腺量纳米粒子在EHRLICH癌模型中防止顺铂诱导的肾毒性，而不会影响顺铂抗癌效果

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ObjectivesCisplatin (CISP) is an effective chemotherapy used in the treatment of various types of cancer, but it causes nephrotoxicity and other adverse effects. Thymoquinone (THY) is an effective anti-inflammatory and antioxidant compound, which might protects against many chemotherapies associated toxicities. However, THY applications are hindered by its poor solubility and low bioavailability. This study evaluated the efficacy of a novel nanoparticle (NP) encapsulting THY to overcome its poor solubility, enhance its bioavilability, efficacy for the protection against CISP-induced nephrotoxicity in an Ehrlich solid carcinoma (ESC) mice model.MethodsFour treatment groups were included: 1) control, 2) tumour, 3) CISP, and 4) CISP?+?NP THY.ResultsThe results showed that NP THY was effective in preventing CISP-induced kidney toxicity in ESC mice and improved its function and pathology. NP THY effectively ameliorated CISP-induced oxidative stress conditions in the kidney tissue via increasing the levels of antioxidants both non-enzymatic (GSH) and enzymatic (SOD and CAT). NP THY, also, significantly reduced CISP-induced kidney inflammation by reducing TNF-α, IL-1β, and NF-kB levels. NP THY didn’t hinder the antitumor activity of CISP as shown by tumour weight and histological examination data.ConclusionsIn conclusion, NP THY could be an adjuvant therapy to CISP cancer treatment to prevent associated nephrotoxicity and other adverse effects without compromising CISP antitumor efficacy.
机译：Objectivescisplatin（CISP）是一种有效的化疗，用于治疗各种类型的癌症，但它会导致肾毒性和其他不良反应。胸腺量（Thy）是一种有效的抗炎和抗氧化剂化合物，可以保护许多相关毒性的化学疗法。然而，您的应用受其溶解度差和低生物利用度的阻碍。本研究评估了一种新型纳米颗粒（NP）包封的疗效，使其克服其差的溶解度差，增强其生物耐受性，对eHRLICH固体癌（ESC）小鼠模型中的CISP诱导的肾毒性保护的疗效。包括： 1）控制，2）肿瘤，3）CISP和4）CISP？+ NP THY.Resultthe结果表明，NP THY在预防ESC小鼠中的CISP诱导肾毒性并改善其功能和病理学。 NP Thy通过增加非酶（GSH）和酶（SOD和猫）的抗氧化剂水平有效地改善了CISP诱导的肾组织中的氧化应激条件。通过降低TNF-α，IL-1β和NF-KB水平，NP THY也显着降低了CISP诱导的肾炎。 NP Thy没有妨碍CISP的抗肿瘤活性，如肿瘤重量和组织学检查数据所示。结论，NP Thy可以是CISP癌症治疗的辅助治疗，以防止相关的肾毒性和其他不良反应而不影响CISP抗肿瘤功效。

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